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A stromal cell free culture system generates mouse pro-t cells that can reconstitute t-cell compartments in vivo
(Wiley-Blackwell, 2014-12-16)
T-cell lymphopenia following BM transplantation or diseases such as AIDS result in immunodeficiency. Novel approaches to ameliorate this situation are urgently required. Herein, we describe a novel stromal cell free culture ...
The pretcr-dependent dn3 to dp transition requires notch signaling, is improved by cxcl12 signaling and is inhibited by il-7 signaling
(Wiley-Blackwell, 2011-10-04)
The requirement for Notch signaling during T-cell development has been extensively studied. Nevertheless, the developmental stage at which it is required and whether additional signaling pathways are needed are still poorly ...