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Meta-analysis confirms bcl2 is an independent prognostic marker in breast cancer
(Springer Nature, 2008-05-29)
Background: A number of protein markers have been investigated as prognostic adjuncts in breast cancer but their translation into clinical practice has been impeded by a lack of appropriate validation. Recently, we showed ...
Micrornas as prognostic indicators and therapeutic targets: potential effect on breast cancer management
(American Association for Cancer Research (AACR), 2008-01-15)
The discovery of microRNAs (miRNA) as novel modulators of gene expression has resulted in a rapidly expanding repertoire of molecules in this family, as reflected in the concomitant expansion of scientific literature. ...
Gene-eluting stents: adenovirus-mediated delivery of enos to the blood vessel wall accelerates re-endothelialization and inhibits restenosis
(Elsevier BV, 2008-10-01)
Drug-eluting stents for coronary artery disease results in inhibition of smooth muscle cell (SMC) and endothelial cells which may increase the risk of stent thrombosis. In this study, we attempted to enhance re-endothelialization ...
Mouse induced pluripotent stem cells
(UPV/EHU Press, 2008-01-01)
The recent discovery that it is possible to directly reprogramme somatic cells to an embryonic stem (ES) cell-like pluripotent state, by retroviral transduction of just four genes (Oct3/4, Sox2, c-Myc and Kif4), represents ...
Effect of progesterone on embryo survival
(Cambridge University Press (CUP), 2008-07-07)
Increased genetic selection over the past 40 years has resulted in a dairy cow with an improved biological efficiency for producing milk but with an associated reduced fertility. Embryo loss is the greatest factor contributing ...
A non-apoptotic role for caspase-9 in muscle differentiation
(The Company of Biologists, 2008-10-28)
Caspases, a family of cysteine proteases most often investigated for their roles in apoptosis, have also been demonstrated to have functions that are vital for the efficient execution of cell differentiation. One such role ...
Newly identified genetic risk variants for celiac disease related to the immune response
(Springer Nature, 2008-03-02)
Our genome-wide association study of celiac disease previously identified risk variants in the IL2-IL21 region. To identify additional risk variants, we genotyped 1,020 of the most strongly associated non-HLA markers in ...
Salivary muc7 is a major carrier of blood group i type o-linked oligosaccharides serving as the scaffold for sialyl lewis x
(Oxford University Press (OUP), 2008-11-29)
Isolation of salivary MUC7 with gel electrophoresis allowed analysis by LC-MS and LC-MS(2) of released O-linked oligosaccharides and a thorough description of the glycosylation of this molecule, where high-molecular-weight ...