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Host recognition of bacterial muramyl dipeptide mediated through nod2
(American Society for Biochemistry & Molecular Biology (ASBMB), 2003-01-04)
NOD2, a protein associated with susceptibility to Crohn's disease, confers responsiveness to bacterial preparations of lipopolysaccharide and peptidoglycan, but the precise moiety recognized remains elusive. Biochemical ...
The trail-receptor-1: trail-receptor-3 and -4 ratio is a predictor for trail sensitivity of cancer cells
(Spandidos Publications, 2009-04-06)
The tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis in many cancer cells. However, a significant proportion of tumours are TRAIL-resistant erecting a major hurdle for a ...
Mnsod protects colorectal cancer cells from trail-induced apoptosis by inhibition of smac/diablo release
(Springer Nature, 2007-07-23)
The mitochondrial enzyme manganese superoxide dismutase (MnSOD) has been shown to have two faces with regard to its role in tumor development. On the one side, it is well documented that overexpression of MnSOD slows down ...
Caspases as therapeutic targets
(Wiley-Blackwell, 2008-09-01)
The development of small molecules to modulate caspase activity offers a novel therapeutic strategy in the treatment of apoptosis-related and inflammatory diseases. Caspases are key mediators of apoptosis and inflammation; ...