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Mediators of endoplasmic reticulum stress-induced apoptosis
(Wiley-Blackwell, 2006-09-01)
The efficient functioning of the endoplasmic reticulum ( ER) is essential for most cellular activities and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins. ...
Stem cells are resistant to trail receptor-mediated apoptosis
(Wiley-Blackwell, 2009-11-01)
New therapeutic approaches aim to eradicate tumours by expression of tumouricidal proteins in the tumour stroma. One such anti-neoplastic protein is tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) because ...
Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment
(Wiley-Blackwell, 2008-05-01)
The application of mesenchyrnal stem cells (MSCs) for myocardial repair following ischemic injury is of strong interest, but current knowledge regarding the survival and retention of differentiation potency of stem cells ...
The mitochondrial death pathway: a promising therapeutic target in diseases
(Wiley-Blackwell, 2009-07-01)
The mitochondrial pathway to apoptosis is a major pathway of physiological cell death in vertebrates. The mitochondrial cell death pathway commences when apoptogenic molecules present between the outer and inner mitochondrial ...