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Don't lose heart - therapeutic value of apoptosis prevention in the treatment of cardiovascular disease
(Wiley-Blackwell, 2005-07-01)
Cardiovascular disease is a leading cause of death worldwide. Loss of function or death of cardiomyocytes is a major contributing factor to these diseases. Cell death in conditions such as heart failure and myocardial ...
Mediators of endoplasmic reticulum stress-induced apoptosis
(Wiley-Blackwell, 2006-09-01)
The efficient functioning of the endoplasmic reticulum ( ER) is essential for most cellular activities and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins. ...
Functionality of ngf-protected pc12 cells following exposure to 6-hydroxydopamine
(Elsevier BV, 2006-12-01)
Stem cells are resistant to trail receptor-mediated apoptosis
(Wiley-Blackwell, 2009-11-01)
New therapeutic approaches aim to eradicate tumours by expression of tumouricidal proteins in the tumour stroma. One such anti-neoplastic protein is tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) because ...
Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment
(Wiley-Blackwell, 2008-05-01)
The application of mesenchyrnal stem cells (MSCs) for myocardial repair following ischemic injury is of strong interest, but current knowledge regarding the survival and retention of differentiation potency of stem cells ...