Search
Now showing items 1-8 of 8
Thiamine plays a critical role in the acid tolerance of listeria monocytogenes
(Oxford University Press (OUP), 2011-11-14)
Understanding the molecular basis of acid tolerance in the food-borne pathogen Listeria monocytogenes is important as this property contributes to survival in the food-chain and enhances survival within infected hosts. The ...
Single nucleotide polymorphisms within the bovine dlk1-dio3 imprinted domain are associated with economically important production traits in cattle
(Oxford University Press (OUP), 2010-09-03)
Previous studies show that DNA sequence variation within the mammalian DLK1-DIO3 imprinted domain influences production traits in domestic livestock, most notably the ovine callipyge phenotype. We assessed genotype-phenotype ...
Isolation, selection and culture methods to enhance clonogenicity of mouse bone marrow derived mesenchymal stromal cell precursors
(Springer Nature, 2015-08-25)
Introduction: Conventionally cultured mouse bone marrow mesenchymal stromal cells (mBM-MSC) are a heterogeneous population that often initially contain contaminating haematopoietic cells. Variability in isolation methods, ...
Biomaterial constructs for delivery of multiple therapeutic genes: a spatiotemporal evaluation of efficacy using molecular beacons
(Public Library of Science (PLoS), 2013-06-03)
Gene therapy is emerging as a potential therapeutic approach for cardiovascular pathogenesis. An appropriate therapy may require multiple genes to enhance therapeutic outcome by modulating inflammatory response and ...
Divergent evolution of the activity and regulation of the glutamate decarboxylase systems in listeria monocytogenes egd-e and 10403s: roles in virulence and acid tolerance
(Public Library of Science (PLoS), 2014-11-11)
The glutamate decarboxylase (GAD) system has been shown to be important for the survival of Listeria monocytogenes in low pH environments. The bacterium can use this faculty to maintain pH homeostasis under acidic conditions. ...
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix
(Springer Nature, 2017-03-27)
The extracellular matrix (ECM) is a major component of the tumor microenvironment, contributing to the regulation of cell survival, proliferation, differentiation and metastasis. In multiple myeloma (MM), interactions ...
Impact of mesenchymal stem cell secreted pai-1 on colon cancer cell migration and proliferation
(Elsevier BV, 2013-06-01)
Targeting the pim kinases in multiple myeloma
(Springer Nature, 2015-07-17)
Multiple myeloma (MM) is a plasma cell malignancy that remains incurable. Novel treatment strategies to improve survival are urgently required. The Pims are a small family of serine/threonine kinases with increased expression ...