Now showing items 1-10 of 12
Loss of plakophilin 2 disrupts heart development in zebrafish
(UPV/EHU Press, 2012-01-01)
The desmosomal armadillo protein plakophilin 2 is the only plakophilin expressed in the heart, and mutations in the human plakophilin 2 gene result in arrhythmogenic right ventricular cardiomyopathy. To investigate loss ...
The expression and roles of nde1 and ndel1 in the adult mammalian central nervous system
(Elsevier BV, 2014-06-01)
A non-apoptotic role for caspase-9 in muscle differentiation
(The Company of Biologists, 2008-10-28)
Caspases, a family of cysteine proteases most often investigated for their roles in apoptosis, have also been demonstrated to have functions that are vital for the efficient execution of cell differentiation. One such role ...
Isolation, selection and culture methods to enhance clonogenicity of mouse bone marrow derived mesenchymal stromal cell precursors
(Springer Nature, 2015-08-25)
Introduction: Conventionally cultured mouse bone marrow mesenchymal stromal cells (mBM-MSC) are a heterogeneous population that often initially contain contaminating haematopoietic cells. Variability in isolation methods, ...
Distinct mechanisms underlie oral vs aboral regeneration in the cnidarianhydractinia echinata
(eLife Sciences Organisation, Ltd., 2015-04-17)
Cnidarians possess remarkable powers of regeneration, but the cellular and molecular mechanisms underlying this capability are unclear. Studying the hydrozoan Hydractinia echinata we show that a burst of stem cell proliferation ...
Distinctive surface glycosylation patterns associated with mouse and human cd4+ regulatory t cells and their suppressive function
(Frontiers Media SA, 2017-08-21)
Regulatory T-cells (Treg) are essential for maintaining immune homeostasis and tolerance. Surface glycosylation is ubiquitous on mammalian cells and regulates diverse biological processes. While it is currently well accepted ...
Unique glycosignature for intervertebral disc and articular cartilage cells and tissues in immaturity and maturity
(Springer Nature, 2016-03-11)
In this study, on/off markers for intervertebral disc (IVD) and articular cartilage (AC) cells (chondrocytes) and distinct glycoprofiles of cell and tissue-types were identified from immaturity to maturity. Three and eleven ...
Primary cilia exist in a small fraction of cells in trabecular bone and marrow
(Springer Nature, 2014-11-15)
Primary cilia are potent mechanical and chemical sensory organelles in cells of bone lineage in tissue culture. Cell culture experiments suggest that primary cilia sense fluid flow and this stimulus is translated through ...
Mesenchymal stem cell effects on t-cell effector pathways
(Springer Nature, 2011-01-01)
Mesenchymal stem (stromal) cells (MSCs) are rare, multipotent progenitor cells that can be isolated and expanded from bone marrow and other tissues. Strikingly, MSCs modulate the functions of immune cells, including T ...
Selective repression of the oncogene cyclin d1 by the tumor suppressor mir-206 in cancers
(Springer Nature, 2014-08-11)
MicroRNAs (miRNAs) are deregulated in cancer and have been shown to exhibit both oncogenic and tumor suppressive functions. Although the functional effects of several miRNAs have been elucidated, those of many remain to ...