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Cb1 and cb2 cannabinoid receptor antagonists prevent minocycline-induced neuroprotection following traumatic brain injury in mice
(Oxford University Press (OUP), 2013-08-19)
Traumatic brain injury (TBI) and its consequences represent one of the leading causes of death in young adults. This lesion mediates glial activation and the release of harmful molecules and causes brain edema, axonal ...
Evidence for intron length conservation in a set of mammalian genes associated with embryonic development
(Springer Nature, 2011-01-01)
Background: We carried out an analysis of intron length conservation across a diverse group of nineteen mammalian species. Motivated by recent research suggesting a role for time delays associated with intron transcription ...
Identification and validation of oncologic mirna biomarkers for luminal a-like breast cancer
(Public Library of Science (PLoS), 2014-01-31)
Introduction: Breast cancer is a common disease with distinct tumor subtypes phenotypically characterized by ER and HER2/neu receptor status. MiRNAs play regulatory roles in tumor initiation and progression, and altered ...
Untying a nanoscale knotted polymer structure to linear chains for efficient gene delivery in vitro and to the brain
(Royal Society of Chemistry (RSC), 2014-01-01)
The purpose of this study was to develop a platform transfection technology, for applications in the brain, which could transfect astrocytes without requiring cell specific functionalization and without the common cause ...
Loss of plakophilin 2 disrupts heart development in zebrafish
(UPV/EHU Press, 2012-01-01)
The desmosomal armadillo protein plakophilin 2 is the only plakophilin expressed in the heart, and mutations in the human plakophilin 2 gene result in arrhythmogenic right ventricular cardiomyopathy. To investigate loss ...
Role of micro-rnas in breast cancer surgery
(Wiley-Blackwell, 2018-01-01)
Background: The management of breast cancer has changed dramatically in the molecular era. Micro-RNAs can contribute to multiple facets of cancer surgery.
Methods: This narrative review, based on years of research on the ...
Different mechanisms for resistance to trastuzumab versus lapatinib in her2- positive breast cancers - role of estrogen receptor and her2 reactivation
(Springer Nature, 2011-11-28)
Introduction: The human epidermal growth factor receptor 2 (HER2)-targeted therapies trastuzumab (T) and lapatinib (L) show high efficacy in patients with HER2-positive breast cancer, but resistance is prevalent. Here we ...
A 3′-untranslated region kras variant and triple-negative breast cancer: a case-control and genetic analysis
(Elsevier BV, 2011-04-01)
Background We previously identified a functional variant in a let-7 microRNA (miRNA) complementary site in the 3'-untranslated region of the KRAS oncogene (rs61764370) which is associated with cancer. We aimed to investigate ...
Role of lentivirus-mediated overexpression of programmed death-ligand 1 on corneal allograft survival
(Wiley-Blackwell, 2012-02-02)
To investigate the role of lentivirus-mediated overexpression of programmed death-ligand 1 (PD-L1) on rat corneal allograft survival. A fully allogeneic rat cornea transplant model was used for in vivo studies. Lentiviral ...