Now showing items 1-10 of 22
Functionality of ngf-protected pc12 cells following exposure to 6-hydroxydopamine
(Elsevier BV, 2006-12-01)
Don't lose heart - therapeutic value of apoptosis prevention in the treatment of cardiovascular disease
Cardiovascular disease is a leading cause of death worldwide. Loss of function or death of cardiomyocytes is a major contributing factor to these diseases. Cell death in conditions such as heart failure and myocardial ...
Hsp27 inhibits cytochrome <i>c</i>-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome <i>c</i>
(Cognizant, LLC, 2001-04-01)
Mitochondrial cytochrome c release in response to pro-apoptotic signals leads to the formation of a cytochrome c/Apaf-1/procaspase-9 complex (the apoptosome) and resultant activation of caspase-9 and caspase-3. Here we ...
Host recognition of bacterial muramyl dipeptide mediated through nod2
(American Society for Biochemistry & Molecular Biology (ASBMB), 2003-01-04)
NOD2, a protein associated with susceptibility to Crohn's disease, confers responsiveness to bacterial preparations of lipopolysaccharide and peptidoglycan, but the precise moiety recognized remains elusive. Biochemical ...
Mediators of endoplasmic reticulum stress-induced apoptosis
The efficient functioning of the endoplasmic reticulum ( ER) is essential for most cellular activities and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins. ...
Adenoviral-mediated overexpression of catalase inhibits endothelial cell proliferation
(American Physiological Society, 2002-12-01)
Although hydrogen peroxide (H2O2) induces proliferation of vascular smooth muscle cells, its role in endothelial cell proliferation is unclear. Our aim was to study the role of hydrogen peroxide in endothelial cell ...
Differential activation of jnk1 isoforms by trail receptors modulate apoptosis of colon cancer cell lines
(Springer Nature, 2009-04-07)
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis on binding to its receptors, death receptor 4 and 5 (DR4, DR5). TRAIL can also activate c-Jun N-terminal kinase (JNK) through the adaptor ...
The apaf-1•procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer
During stress-induced apoptosis, the initiator caspase-9 is activated by the Apaf-1 apoptosome and must remain bound to retain significant catalytic activity. Nevertheless, in apoptotic cells the vast majority of processed ...
Meta-analysis confirms bcl2 is an independent prognostic marker in breast cancer
(Springer Nature, 2008-05-29)
Background: A number of protein markers have been investigated as prognostic adjuncts in breast cancer but their translation into clinical practice has been impeded by a lack of appropriate validation. Recently, we showed ...
Adrb3 adrenergic receptor is a key regulator of human myometrial apoptosis and inflammation during chorioamnionitis1
(Oxford University Press (OUP), 2008-03-01)
The pathophysiology underlying preterm labor triggered by inflammatory conditions such as chorioamnionitis remains largely unclear. It has already been suggested that beta-3 adrenergic (ADRB3) agonists might be of interest ...