Now showing items 1-10 of 22
Mesenchymal stem cells expressing trail lead to tumour growth inhibition in an experimental lung cancer model
Lung cancer is a major public health problem in the western world, and gene therapy strategies to tackle this disease systemically are often impaired by inefficient delivery of the vector to the tumour tissue. Some of the ...
Mnsod protects colorectal cancer cells from trail-induced apoptosis by inhibition of smac/diablo release
(Springer Nature, 2007-07-23)
The mitochondrial enzyme manganese superoxide dismutase (MnSOD) has been shown to have two faces with regard to its role in tumor development. On the one side, it is well documented that overexpression of MnSOD slows down ...
Differential activation of jnk1 isoforms by trail receptors modulate apoptosis of colon cancer cell lines
(Springer Nature, 2009-04-07)
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis on binding to its receptors, death receptor 4 and 5 (DR4, DR5). TRAIL can also activate c-Jun N-terminal kinase (JNK) through the adaptor ...
The apaf-1•procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer
During stress-induced apoptosis, the initiator caspase-9 is activated by the Apaf-1 apoptosome and must remain bound to retain significant catalytic activity. Nevertheless, in apoptotic cells the vast majority of processed ...
Adrb3 adrenergic receptor is a key regulator of human myometrial apoptosis and inflammation during chorioamnionitis1
(Oxford University Press (OUP), 2008-03-01)
The pathophysiology underlying preterm labor triggered by inflammatory conditions such as chorioamnionitis remains largely unclear. It has already been suggested that beta-3 adrenergic (ADRB3) agonists might be of interest ...
Hsp27 inhibits cytochrome <i>c</i>-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome <i>c</i>
(Cognizant, LLC, 2001-04-01)
Mitochondrial cytochrome c release in response to pro-apoptotic signals leads to the formation of a cytochrome c/Apaf-1/procaspase-9 complex (the apoptosome) and resultant activation of caspase-9 and caspase-3. Here we ...
Host recognition of bacterial muramyl dipeptide mediated through nod2
(American Society for Biochemistry & Molecular Biology (ASBMB), 2003-01-04)
NOD2, a protein associated with susceptibility to Crohn's disease, confers responsiveness to bacterial preparations of lipopolysaccharide and peptidoglycan, but the precise moiety recognized remains elusive. Biochemical ...
Functionality of ngf-protected pc12 cells following exposure to 6-hydroxydopamine
(Elsevier BV, 2006-12-01)
Stem cells are resistant to trail receptor-mediated apoptosis
New therapeutic approaches aim to eradicate tumours by expression of tumouricidal proteins in the tumour stroma. One such anti-neoplastic protein is tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) because ...
Proinflammatory action of the antiinflammatory drug infliximab in tumor necrosis factor receptor-associated periodic syndrome
Objective. Tumor necrosis factor receptor (TNFR) -associated periodic syndrome (TRAPS) is an autosomal-dominant autoinflammatory condition caused by mutations in the TNFRSFIA gene. Unlike other autoinflammatory diseases ...