Now showing items 1-10 of 12
Ddk dependent regulation of top2a at centromeres revealed by a chemical genetics approach
(Oxford University Press (OUP), 2016-07-12)
In eukaryotic cells the CDC7/DBF4 kinase, also known as DBF4-dependent kinase (DDK), is required for the firing of DNA replication origins. CDC7 is also involved in replication stress responses and its depletion sensitises ...
Hypoxic activation of atr and the suppression of the initiation of dna replication through cdc6 degradation
(Springer Nature, 2011-12-19)
Many severely hypoxic cells fail to initiate DNA replication, but the mechanism underlying this observation is unknown. Specifically, although the ataxia-telangiectasia-rad3 related (ATR) kinase has been shown to be activated ...
Microrna-29a regulates the benzo[a]pyrene dihydrodiol epoxide-induced dna damage response through cdc7 kinase in lung cancer cells
(Springer Nature, 2013-07-01)
Cdc7 kinase is a key regulator of DNA replication and has an important role in the cellular DNA damage response by controlling checkpoint signaling and cell survival. Yet, how the activity of Cdc7 kinase is regulated is ...
Interplay of dna damage and cell cycle signaling at the level of human replication protein a
(Elsevier BV, 2014-09-01)
Dna polymerase η modulates replication fork progression and dna damage responses in platinum-treated human cells
(Springer Nature, 2013-11-20)
Human cells lacking DNA polymerase eta (pol eta) are sensitive to platinum-based cancer chemotherapeutic agents. Using DNA combing to directly investigate the role of pol eta in bypass of platinum-induced DNA lesions in ...
A high through-put screen for small molecules modulating mcm2 phosphorylation identifies ryuvidine as an inducer of the dna damage response
(Public Library of Science (PLoS), 2014-06-05)
DNA replication is an essential process for cell division and as such it is a process that is directly targeted by several anticancer drugs. CDC7 plays an essential role in the activation of replication origins and has ...
Promoter hijack reveals pericentrin functions in mitosis and the dna damage response
(Informa UK Limited, 2013-02-15)
Centrosomes, the principal microtubule-organizing centers of animal somatic cells, consist of two centrioles embedded in the pericentriolar material (PCM). Pericentrin is a large PCM protein that is required for normal PCM ...
Repression of g1/s transcription is mediated via interaction of the gtb motifs of nrm1 and whi5 with swi6
(American Society for Microbiology, 2013-02-04)
In Saccharomyces cerevisiae, G(1)/S transcription factors MBF and SBF regulate a large family of genes important for entry to the cell cycle and DNA replication and repair. Their regulation is crucial for cell viability, ...
Cdc7-dependent and -independent phosphorylation of claspin in the induction of the dna replication checkpoint
(Informa UK Limited, 2013-05-15)
Claspin is a critical mediator protein in the DNA replication checkpoint, responsible for ATR-dependent activation of the effector kinase Chk1. Cdc7, an essential kinase required for the initiation of DNA replication, can ...
Oscillation of apc/c activity during cell cycle arrest promotes centrosome amplification
(The Company of Biologists, 2012-09-06)
Centrosome duplication is licensed by the disengagement, or 'uncoupling', of centrioles during late mitosis. However, arrest of cells in G2 can trigger premature centriole disengagement. Here, we show that premature ...