Now showing items 1-10 of 12
Ddk dependent regulation of top2a at centromeres revealed by a chemical genetics approach
(Oxford University Press (OUP), 2016-07-12)
In eukaryotic cells the CDC7/DBF4 kinase, also known as DBF4-dependent kinase (DDK), is required for the firing of DNA replication origins. CDC7 is also involved in replication stress responses and its depletion sensitises ...
Interplay of dna damage and cell cycle signaling at the level of human replication protein a
(Elsevier BV, 2014-09-01)
Hypoxic activation of atr and the suppression of the initiation of dna replication through cdc6 degradation
(Springer Nature, 2011-12-19)
Many severely hypoxic cells fail to initiate DNA replication, but the mechanism underlying this observation is unknown. Specifically, although the ataxia-telangiectasia-rad3 related (ATR) kinase has been shown to be activated ...
Microrna-29a regulates the benzo[a]pyrene dihydrodiol epoxide-induced dna damage response through cdc7 kinase in lung cancer cells
(Springer Nature, 2013-07-01)
Cdc7 kinase is a key regulator of DNA replication and has an important role in the cellular DNA damage response by controlling checkpoint signaling and cell survival. Yet, how the activity of Cdc7 kinase is regulated is ...
A high through-put screen for small molecules modulating mcm2 phosphorylation identifies ryuvidine as an inducer of the dna damage response
(Public Library of Science (PLoS), 2014-06-05)
DNA replication is an essential process for cell division and as such it is a process that is directly targeted by several anticancer drugs. CDC7 plays an essential role in the activation of replication origins and has ...
Dna polymerase η modulates replication fork progression and dna damage responses in platinum-treated human cells
(Springer Nature, 2013-11-20)
Human cells lacking DNA polymerase eta (pol eta) are sensitive to platinum-based cancer chemotherapeutic agents. Using DNA combing to directly investigate the role of pol eta in bypass of platinum-induced DNA lesions in ...
The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies
(Oxford University Press (OUP), 2011-07-01)
Retinoblastoma protein (pRb) is a ubiquitous 928-amino acid cell cycle regulatory molecule with diverse biologic activities. One critical function of pRb is the control of the G(1)-to-S phase checkpoint of the cell cycle. ...
Cdc7-dependent and -independent phosphorylation of claspin in the induction of the dna replication checkpoint
(Informa UK Limited, 2013-05-15)
Claspin is a critical mediator protein in the DNA replication checkpoint, responsible for ATR-dependent activation of the effector kinase Chk1. Cdc7, an essential kinase required for the initiation of DNA replication, can ...
Promoter hijack reveals pericentrin functions in mitosis and the dna damage response
(Informa UK Limited, 2013-02-15)
Centrosomes, the principal microtubule-organizing centers of animal somatic cells, consist of two centrioles embedded in the pericentriolar material (PCM). Pericentrin is a large PCM protein that is required for normal PCM ...
Parg is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(adp-ribose) upon prolonged replicative stress
(Oxford University Press (OUP), 2014-06-06)
Poly(ADP-ribosyl)ation is involved in numerous biological processes including DNA repair, transcription and cell death. Cellular levels of poly(ADP-ribose) (PAR) are regulated by PAR polymerases (PARPs) and the degrading ...