Now showing items 1-6 of 6
A chromatin-independent role of polycomb-like 1 to stabilize p53 and promote cellular quiescence
(Cold Spring Harbor Laboratory, 2015-10-22)
Polycomb-like proteins 1-3 (PCL1-3) are substoichiometric components of the Polycomb-repressive complex 2 (PRC2) that are essential for association of the complex with chromatin. However, it remains unclear why three ...
Isolated cutaneous metastasis of uterine leiomyosarcoma: case report and review of literature
(Springer Nature, 2012-01-01)
A 54 year old lady presented for routine excision of a scalp lesion thought clinically to represent a sebaceous cyst of the right occiput. 4 years earlier she underwent total abdominal hysterectomy and right salpingo-oophorectomy ...
A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining
(The Royal Society, 2016-09-01)
Loss of p53, a transcription factor activated by cellular stress, is a frequent event in cancer. The role of p53 in tumour suppression is largely attributed to cell fate decisions. Here, we provide evidence supporting a ...
Deregulated expression of the hsp40 family members auxilin-1 and -2 is indicative of proteostasis imbalance and predicts patient outcome in ph+ leukemia
(Springer Nature, 2015-12-01)
Background: Proteostasis is defined by the orchestrated control of anabolic and catabolic protein pathways. Disruption of proteostasis results in cell stress and adaptation to proteostasis imbalance is mediated by adaptive ...
P53-mediated induction of noxa and p53aip1 requires nfκb
(Informa UK Limited, 2010-03-01)
The intricate regulation of cell survival and cell death is critical for the existence of both normal and transformed cells. Two factors central to these processes are p53 and NF kappa B, with both factors having ascribed ...
Micrornas in colorectal cancer: function, dysregulation and potential as novel biomarkers
(Elsevier BV, 2011-08-01)