Now showing items 1-5 of 5
Regulating immunogenicity and tolerogenicity of bone marrow-derived dendritic cells through modulation of cell surface glycosylation by dexamethasone treatment
(Frontiers Media SA, 2017-10-30)
Dendritic cellular therapies and dendritic cell vaccines show promise for the treatment of autoimmune diseases, the prolongation of graft survival in transplantation, and in educating the immune system to fight cancers. ...
The sialyltransferase st3gal6 influences homing and survival in multiple myeloma
(American Society of Hematology, 2014-07-24)
Glycosylation is a stepwise procedure of covalent attachment of oligosaccharide chains to proteins or lipids, and alterations in this process, especially increased sialylation, have been associated with malignant transformation ...
Targeting selectins and their ligands in cancer
(Frontiers Media SA, 2016-04-18)
Aberrant glycosylation is a hallmark of cancer cells with increased evidence pointing to a role in tumor progression. In particular, aberrant sialylation of glycoproteins and glycolipids has been linked to increased immune ...
E-selectin ligands recognised by heca452 induce drug resistance in myeloma, which is overcome by the e-selectin antagonist, gmi-1271
(Springer Nature, 2017-04-25)
Multiple myeloma (MM) is characterized by the clonal expansion and metastatic spread of malignant plasma cells to multiple sites in the bone marrow (BM). Recently, we implicated the sialyltransferase ST3Gal-6, an enzyme ...
Fucosylated chondroitin sulfates from the body wall of the sea cucumberholothuria forskali
(American Society for Biochemistry & Molecular Biology (ASBMB), 2014-08-21)
Fucosylated chondroitin sulfate (fCS) extracted from the sea cucumber Holothuria forskali is composed of the following repeating trisaccharide unit: -&gt; 3)GalNAc beta 4,6S(1 -&gt; 4) [Fuc alpha X(1 -&gt; ...