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C-nap1 and rootletin restrain dna damage-induced centriole splitting and facilitate ciliogenesis
(Informa UK Limited, 2012-10-15)
Cilia are found on most human cells and exist as motile cilia or non-motile primary cilia. Primary cilia play sensory roles in transducing various extracellular signals, and defective ciliary functions are involved in a ...
Interplay of dna damage and cell cycle signaling at the level of human replication protein a
(Elsevier BV, 2014-09-01)
Centriole splitting caused by loss of the centrosomal linker protein c-nap1 reduces centriolar satellite density and impedes centrosome amplification
(American Society for Cell Biology (ASCB), 2017-01-18)
Duplication of the centrosomes is a tightly regulated process. Abnormal centrosome numbers can impair cell division and cause changes in how cells migrate. Duplicated centrosomes are held together by a proteinaceous linker ...
Oscillation of apc/c activity during cell cycle arrest promotes centrosome amplification
(The Company of Biologists, 2012-09-06)
Centrosome duplication is licensed by the disengagement, or 'uncoupling', of centrioles during late mitosis. However, arrest of cells in G2 can trigger premature centriole disengagement. Here, we show that premature ...