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The janus face of death receptor signaling during tumor immunoediting
(Frontiers Media SA, 2016-10-31)
Cancer immune surveillance is essential for the inhibition of carcinogenesis. Malignantly transformed cells can be recognized by both the innate and adaptive immune systems through different mechanisms. Immune effector ...
The pyrrolo-1,5-benzoxazepine, pbox-15, enhances trail-induced apoptosis by upregulation of dr5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells
(Spandidos Publications, 2016-05-11)
Apoptotic defects are frequently associated with poor outcome in pediatric acute lymphoblastic leukaemia (ALL) hence there is an ongoing demand for novel strategies that counteract apoptotic resistance. The death ligand ...
Resistance to trail in non-transformed cells is due to multiple redundant pathways
(Springer Nature, 2013-07-01)
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine and a selective inducer of apoptosis in a range of tumour cells, but not in normal, untransformed cells. A large number of chemotherapeutics ...