Now showing items 1-2 of 2
Methyl-cytosine-driven structural changes enhance adduction kinetics of an exon 7 fragment of the p53 gene
(Springer Nature, 2017-01-19)
Methylation of cytosine (C) at C-phosphate-guanine (CpG) sites enhances reactivity of DNA towards electrophiles. Mutations at CpG sites on the p53 tumor suppressor gene that can result from these adductions are in turn ...
On the molecular basis of uracil recognition in dna: comparative study of t-a versus u-a structure, dynamics and open base pair kinetics
(Oxford University Press (OUP), 2010-09-28)
Uracil (U) can be found in DNA as a mismatch paired either to adenine (A) or to guanine (G). Removal of U from DNA is performed by a class of enzymes known as uracil-DNA-glycosylases (UDG). Recent studies suggest that ...