Now showing items 1-3 of 3
Heritability in the efficiency of nonsense-mediated mrna decay in humans
(Public Library of Science (PLoS), 2010-07-21)
Background: In eukaryotes mRNA transcripts of protein-coding genes in which an intron has been retained in the coding region normally result in premature stop codons and are therefore degraded through the nonsense-mediated ...
Identification and characterization of novel associations in the casp8/als2cr12 region on chromosome 2 with breast cancer risk
(Oxford University Press (OUP), 2014-08-28)
Previous studies have suggested that polymorphisms in CASP8 on chromosome 2 are associated with breast cancer risk. To clarify the role of CASP8 in breast cancer susceptibility, we carried out dense genotyping of this ...
Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis
(Springer Nature, 2015-02-05)
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis and, despite the larger estimated heritability for PsA, the majority of genetic susceptibility loci identified to date are shared with ...