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Mutsβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells
(Oxford University Press (OUP), 2012-08-30)
Trinucleotide repeat (TNR) expansions cause at least 17 heritable neurological diseases, including Huntington's disease. Expansions are thought to arise from abnormal processing of TNR DNA by specific trans-acting proteins. ...
Mutsβ abundance and msh3 atp hydrolysis activity are important drivers of ctg•cag repeat expansions
(Oxford University Press (OUP), 2017-07-21)
CTG circle CAG repeat expansions cause at least twelve inherited neurological diseases. Expansions require the presence, not the absence, of the mismatch repair protein MutS beta (Msh2-Msh3 heterodimer). To evaluate ...