Browsing University of Galway Support Services by Subject "hypoxia"
Now showing items 1-14 of 14
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1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (ks119): a cytotoxic prodrug with two stable conformations differing in biological and physical properties
(Wiley-Blackwell, 2011-09-06)The anticancer prodrug 1,2-bis(methylsulfonyl)-1-( 2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) selectively releases a short-lived cytotoxin following enzymatic reduction in hypoxic environments ... -
Differential response of mouse thymic epithelial cell types to ionizing radiation-induced dna damage
(Frontiers Media SA, 2017-04-13)Thymic epithelial cells (TECs) are the main components of the thymic stroma that support and control T-cell development. Preparative regimens using DNA-damaging agents, such as total body irradiation and/or chemotherapeutic ... -
Dn2 thymocytes activate a specific robust dna damage response to ionizing radiation-induced dna double-strand breaks
(Frontiers Media SA, 2018-06-11)For successful bone marrow transplantation (BMT), a preconditioning regime involving chemo and radiotherapy is used that results in DNA damage to both hematopoietic and stromal elements. Following radiation exposure, it ... -
Hypoxia enhances the radioresistance of mouse mesenchymal stromal cells
(Wiley-Blackwell, 2014-07-15)Mesenchymal stromal cells (MSCs) are radioresistant bone marrow progenitors that support hematopoiesis and its reconstitution following total body irradiation. MSCs reside in hypoxic niches within the bone marrow and tumor ... -
Hypoxic activation of atr and the suppression of the initiation of dna replication through cdc6 degradation
(Springer Nature, 2011-12-19)Many severely hypoxic cells fail to initiate DNA replication, but the mechanism underlying this observation is unknown. Specifically, although the ataxia-telangiectasia-rad3 related (ATR) kinase has been shown to be activated ... -
Increased expression of endoplasmic reticulum stress-related signaling pathway molecules in multiple sclerosis lesions
(Oxford University Press (OUP), 2008-03-01)Activation of endoplasmic reticulum (ER) stress-related cell signals has been reported in several neurologic disorders and may contribute to neurodegeneration. Endoplasmic reticulum stress is also linked to ischemic injury. ... -
Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia
(Springer Nature, 2011-01-01)Introduction: A combination of gene and cell therapies has the potential to significantly enhance the therapeutic value of mesenchymal stem cells (MSCs). The development of efficient gene delivery methods is essential if ... -
Low oxygen tension and macromolecular crowding accelerate extracellular matrix deposition in human corneal fibroblast culture
(Wiley-Blackwell, 2017-01-01) -
Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment
(Wiley-Blackwell, 2008-05-01)The application of mesenchyrnal stem cells (MSCs) for myocardial repair following ischemic injury is of strong interest, but current knowledge regarding the survival and retention of differentiation potency of stem cells ... -
Ocean urea fertilization for carbon credits poses high ecological risks
(Elsevier BV, 2008-06-01) -
Radiation-induced alterations of osteogenic and chondrogenic differentiation of human mesenchymal stem cells
(Public Library of Science (PLoS), 2015-04-02)While human mesenchymal stem cells (hMSCs), either in the bone marrow or in tumour microenvironment could be targeted by radiotherapy, their response is poorly understood. The oxic effects on radiosensitivity, cell cycle ... -
The transcription factor hif-1 enhances the radio-resistance of mouse mscs
(Frontiers Media SA, 2018-04-26)Mesenchymal stromal cells (MSCs) are multipotent progenitors supporting bone marrow hematopoiesis. MSCs have an efficient DNA damage response (DDR) and are consequently relatively radio-resistant cells. Therefore, MSCs are ... -
Tumor microenvironment-based feed-forward regulation of nos2 in breast cancer progression
(Proceedings of the National Academy of Sciences, 2014-04-14)Inflammation is widely recognized as an inducer of cancer progression. The inflammation-associated enzyme, inducible nitric oxide synthase (NOS2), has emerged as a candidate oncogene in estrogen receptor (ER)-negative ...