Browsing University of Galway Support Services by Subject "cytotoxicity"
Now showing items 1-9 of 9
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1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (ks119): a cytotoxic prodrug with two stable conformations differing in biological and physical properties
(Wiley-Blackwell, 2011-09-06)The anticancer prodrug 1,2-bis(methylsulfonyl)-1-( 2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) selectively releases a short-lived cytotoxin following enzymatic reduction in hypoxic environments ... -
Antioxidant-mediated inhibition of the heat shock response leads to apoptosis
(Wiley-Blackwell, 1999-02-19) -
Effects of long-term exposure of gelatinated and non-gelatinated cadmium telluride quantum dots on differentiated pc12 cells
(Springer Nature, 2012-01-01)Background: The inherent toxicity of unmodified Quantum Dots (QDs) is a major hindrance to their use in biological applications. To make them more potent as neuroprosthetic and neurotherapeutic agents, thioglycolic acid ... -
Evaluation of phenolic content variability along with antioxidant, antimicrobial, and cytotoxic potential of selected traditional medicinal plants from india
(Frontiers Media SA, 2016-03-31)Plants have been used since ancient times as an important source of biologically active substances. The aim of the present study was to investigate the phytochemical constituents (flavonoids and phenolics), antioxidant ... -
Lycopodium clavatum and lycopodium complanatum subsp. chamaecyparissus ekstrelerinin antiprotozoal aktivitesi ve sitotoksisitesi
(LookUs Bilisim, Ltd., 2013-01-01)Objective: We assessed in vitro antiprotozoal activity of the petroleum ether (PE), chloroform (CHCl3), methanol (MeOH) and alkaloid (ALK) extracts of the ferns Lycopodium clavatum L. (LC) and L. complanatum L. subsp. ... -
Magnetic core-shell nanoparticles for drug delivery by nebulization
(Springer Nature, 2013-01-01)Background: Aerosolized therapeutics hold great potential for effective treatment of various diseases including lung cancer. In this context, there is an urgent need to develop novel nanocarriers suitable for drug delivery ... -
New insights into the causes of human illness due to consumption of azaspiracid contaminated shellfish
(Springer Nature, 2015-04-30)Azaspiracid (AZA) poisoning was unknown until 1995 when shellfish harvested in Ireland caused illness manifesting by vomiting and diarrhoea. Further in vivo/vitro studies showed neurotoxicity linked with AZA exposure. ... -
Phosphate diester cleavage, dna interaction and cytotoxic activity of a bimetallic bis(1,4,7-triazacyclononane) zinc complex
(Wiley-Blackwell, 2014-06-24)The dinuclear zinc complex [Zn-2{bcmp(-H)}(mu-Cl)](ClO4)(2)center dot H2O {bcmp = 2,6-bis(1,4,7-triazacyclonon-1-ylmethyl)-4-methylphenol} has been synthesized and structurally characterized. The DNA binding affinity was ...