Browsing University of Galway Support Services by Author "Gabius, Hans-Joachim"
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Lectins: getting familiar with translators of the sugar code
André, Sabine; Kaltner, Herbert; Manning, Joachim; Murphy, Paul; Gabius, Hans-Joachim (MDPI AG, 2015-01-22)The view on the significance of the presence of glycans in glycoconjugates is undergoing a paradigmatic change. Initially mostly considered to be rather inert and passive, the concept of the sugar code identifies glycans ... -
Multivalent carbohydrate-lectin interactions: how synthetic chemistry enables insights into nanometric recognition
Roy, René; Murphy, Paul; Gabius, Hans-Joachim (MDPI AG, 2016-05-13)Glycan recognition by sugar receptors (lectins) is intimately involved in many aspects of cell physiology. However, the factors explaining the exquisite selectivity of their functional pairing are not yet fully understood. ... -
Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles
André, Sabine; Velasco-Torrijos, Trinidad; Leyden, Rosaria; Gouin, Sebastien; Tosin, Manuela; Murphy, Paul V.; Gabius, Hans-Joachim (Royal Society of Chemistry (RSC), 2009-01-01)The conjugation of carbohydrates to synthetic scaffolds has the goal of preparing potent inhibitors of lectin binding. We herein report the synthesis of a panel of bivalent compounds (cyclophane and terephthalamide-derivatives) ... -
Synthesis of bivalent lactosides based on terephthalamide,n,n′-diglucosylterephthalamide, and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins
Leyden, Rosaria; Velasco-Torrijos, Trinidad; André, Sabine; Gouin, Sebastien; Gabius, Hans-Joachim; Murphy, Paul V. (American Chemical Society (ACS), 2009-12-04)Glycan recognition by lectins initiates clinically relevant processes such as toxin binding or tumor spread. Thus, the development of potent inhibitors has a medical perspective. Toward this goal, we report the synthesis ... -
The third dimension of reading the sugar code by lectins: design of glycoclusters with cyclic scaffolds as tools with the aim to define correlations between spatial presentation and activity
Murphy, Paul; André, Sabine; Gabius, Hans-Joachim (MDPI AG, 2013-04-04)Coding of biological information is not confined to nucleic acids and proteins. Endowed with the highest level of structural versatility among biomolecules, the glycan chains of cellular glycoconjugates are well-suited to ...