Browsing University of Galway Support Services by Author "Earnshaw, William C"
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Analysis of scc1-deficient cells defines a key metaphase role of vertebrate cohesin in linking sister kinetochores
Vagnarelli, Paola; Morrison, Ciaran; Dodson, Helen; Sonoda, Eiichiro; Takeda, Shunichi; Earnshaw, William C (Wiley-Blackwell, 2004-02-01)Cleavage of the cohesin subunit Scc1p/Mcd1p/Rad21 permits sister chromatid separation and is considered to trigger anaphase onset. It has also been suggested that the cohesin complex is essential for chromosome condensation ... -
Centrosome amplification induced by dna damage occurs during a prolonged g2 phase and involves atm
Dodson, Helen; Bourke, Emer; Jeffers, Liam J; Vagnarelli, Paola; Sonoda, Eiichiro; Takeda, Shunichi; Earnshaw, William C; Merdes, Andreas; Morrison, Ciaran (Wiley-Blackwell, 2004-09-09)Centrosomes are the principal microtubule organising centres in somatic cells. Abnormal centrosome number is common in tumours and occurs after gamma-irradiation and in cells with mutations in DNA repair genes. To investigate ...