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dc.contributor.authorSzegezdi, Eva
dc.contributor.authorLogue, Susan E
dc.contributor.authorGorman, Adrienne M.
dc.contributor.authorSamali, Afshin
dc.date.accessioned2018-08-24T08:26:30Z
dc.date.available2018-08-24T08:26:30Z
dc.date.issued2006-09-01
dc.identifier.citationSzegezdi, Eva; Logue, Susan E; Gorman, Adrienne M; Samali, Afshin (2006). Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO reports 7 (9), 880-885
dc.identifier.issn1469-221X,1469-3178
dc.identifier.urihttp://hdl.handle.net/10379/9922
dc.description.abstractThe efficient functioning of the endoplasmic reticulum ( ER) is essential for most cellular activities and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins. ER transmembrane receptors detect the onset of ER stress and initiate the unfolded protein response ( UPR) to restore normal ER function. If the stress is prolonged, or the adaptive response fails, apoptotic cell death ensues. Many studies have focused on how this failure initiates apoptosis, as ER stress- induced apoptosis is implicated in the pathophysiology of several neurodegenerative and cardiovascular diseases. In this review, we examine the role of the molecules that are activated during the UPR in order to identify the molecular switch from the adaptive phase to apoptosis. We discuss how the activation of these molecules leads to the commitment of death and the mechanisms that are responsible for the final demise of the cell.
dc.publisherWiley-Blackwell
dc.relation.ispartofEMBO reports
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectapoptosis
dc.subjectbcl2 family
dc.subjecter stress
dc.subjectunfolded protein response
dc.subjectunfolded protein response
dc.subjectinduced cell-death
dc.subjecter-stress
dc.subjectinducible protein
dc.subjectproapoptotic bax
dc.subjectactivation
dc.subjectcaspase-12
dc.subjectire1
dc.subjectp58(ipk)
dc.subjectbcl-2
dc.titleMediators of endoplasmic reticulum stress-induced apoptosis
dc.typeArticle
dc.identifier.doi10.1038/sj.embor.7400779
dc.local.publishedsourcehttp://embor.embopress.org/content/embor/7/9/880.full.pdf
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