dc.contributor.author | Reeve, Janice L. V. | |
dc.contributor.author | Duffy, Angela M. | |
dc.contributor.author | O'Brien, Timothy | |
dc.contributor.author | Samali, Afshin | |
dc.date.accessioned | 2018-08-24T08:26:16Z | |
dc.date.available | 2018-08-24T08:26:16Z | |
dc.date.issued | 2005-07-01 | |
dc.identifier.citation | Reeve, Janice L. V. Duffy, Angela M.; O'Brien, Timothy; Samali, Afshin (2005). Don't lose heart - therapeutic value of apoptosis prevention in the treatment of cardiovascular disease. Journal of Cellular and Molecular Medicine 9 (3), 609-622 | |
dc.identifier.issn | 1582-1838,1582-4934 | |
dc.identifier.uri | http://hdl.handle.net/10379/9810 | |
dc.description.abstract | Cardiovascular disease is a leading cause of death worldwide. Loss of function or death of cardiomyocytes is a major contributing factor to these diseases. Cell death in conditions such as heart failure and myocardial infarction is associated with apoptosis. Apoptotic pathways have been well studied in non-myocytes and it is thought that similar pathways exist in cardiomyocytes. These pathways include death initiated by ligation of membrane-bound death receptors, release of pro-apoptotic factors from mitochondria or stress at the endoplasmic reticulum. The key regulators of apoptosis include inhibitors of caspases (IAPs), the Bcl-2 family of proteins, growth factors, stress proteins, calcium and oxidants. The highly organized and predictive nature of apoptotic signaling means it is amenable to manipulation. A thorough understanding of the apoptotic process would facilitate intervention at the most suitable points, alleviating myocardium decline and dysfunction. This review summarizes the mechanisms underlying apoptosis and the mediators/regulators involved in these signaling pathways. We also discuss how the potential therapeutic value of these molecules could be harnessed. | |
dc.publisher | Wiley-Blackwell | |
dc.relation.ispartof | Journal of Cellular and Molecular Medicine | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | cardiovascular disease | |
dc.subject | apoptosis | |
dc.subject | ischemia/reperfusion (i/r) | |
dc.subject | mitochondria | |
dc.subject | anti-apoptosis | |
dc.subject | therapy | |
dc.subject | necrosis-factor-alpha | |
dc.subject | adenine-nucleotide translocator | |
dc.subject | permeability transition pore | |
dc.subject | endoplasmic-reticulum stress | |
dc.subject | ischemia-reperfusion injury | |
dc.subject | acute myocardial-infarction | |
dc.subject | caspase recruitment domain | |
dc.subject | cardiac myocyte apoptosis | |
dc.subject | fas-mediated apoptosis | |
dc.subject | cell-death proteases | |
dc.title | Don't lose heart - therapeutic value of apoptosis prevention in the treatment of cardiovascular disease | |
dc.type | Article | |
dc.identifier.doi | 10.1111/j.1582-4934.2005.tb00492.x | |
dc.local.publishedsource | http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2005.tb00492.x/pdf | |
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