An evaluation of preoperative ca 15-3 measurement in primary breast carcinoma
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O'Hanlon, DM; Kerin, MJ; Kent, P; Maher, D; Grimes, H; Given, HF (1995). An evaluation of preoperative ca 15-3 measurement in primary breast carcinoma. British Journal of Cancer 71 (6), 1288-1291
In this study of 500 patients with breast carcinoma, we have prospectively assessed the role of preoperative CA 15-3 as a marker of disease burden over a 7 year period. CA 15-3 levels at presentation correlate with stage of disease, tumour size, lymph node status, the presence of metastases and lymphocyte infiltration into the tumour. CA 15-3 alone is not an independent prognostic indicator, although a serum level of > 40 U ml(-1) has a positive predictive value of 83% for the presence of advanced disease. We recommend the routine use of this marker in the preoperative assessment of primary breast carcinoma.