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dc.contributor.authorO??Flynn, Padraig M.
dc.contributor.authorRoche, Ellen T.
dc.contributor.authorPandit, Abhay S.
dc.date.accessioned2018-08-24T08:25:54Z
dc.date.available2018-08-24T08:25:54Z
dc.date.issued2005-07-01
dc.identifier.citationO??Flynn, Padraig M. Roche, Ellen T.; Pandit, Abhay S. (2005). Generating an ex vivo vascular model. ASAIO Journal 51 (4), 426-433
dc.identifier.issn1058-2916
dc.identifier.urihttp://hdl.handle.net/10379/9646
dc.description.abstractRealistic ex vivo anthropometric vascular environments are required for endovascular device optimization and for preclinical evaluation of interventional procedures. The objective of this research is to build an anthropomorphic model of the human carotid artery. The combination of magnetic resonance angiography image processing and computer-aided design and manufacturing techniques allowed fabrication of multicomponent morphologically precise casts of the carotid artery. The lost core technique was used to produce a hollow vessel prototype incorporating polyvinyl alcohol cryogel (PVA-C) as a tissue-mimicking vessel wall material. PVA-C was mechanically characterized by uniaxial tensile testing after different numbers of freeze/thaw cycles. The novel model construction approach outlined in this study accounts for the morphologic complexities of the human vasculature, and proved successful for the production of realistic compliant ex vivo arterial model.
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.relation.ispartofASAIO Journal
dc.subjectcomputational fluid-dynamics
dc.subjecthuman carotid bifurcation
dc.subjectabdominal aortic-aneurysms
dc.subjectmagnetic-resonance images
dc.subjectpolyvinyl-alcohol cryogel
dc.subjectblood-flow
dc.subjectendovascular repair
dc.subjectultrasonic doppler
dc.subjectvessel phantom
dc.subjectelastic model
dc.titleGenerating an ex vivo vascular model
dc.typeArticle
dc.identifier.doi10.1097/01.mat.0000170629.92765.bb
dc.local.publishedsourcehttp://pdfs.journals.lww.com/asaiojournal/2005/07000/Generating_an_Ex_Vivo_Vascular_Model.18.pdf?token=method|ExpireAbsolute;source|Journals;ttl|1503140672159;payload|mY8D3u1TCCsNvP5E421JYK6N6XICDamxByyYpaNzk7FKjTaa1Yz22MivkHZqjGP4kdS2v0J76WGAnHACH69s21Csk0OpQi3YbjEMdSoz2UhVybFqQxA7lKwSUlA502zQZr96TQRwhVlocEp/sJ586aVbcBFlltKNKo+tbuMfL73hiPqJliudqs17cHeLcLbV/CqjlP3IO0jGHlHQtJWcICDdAyGJMnpi6RlbEJaRheGeh5z5uvqz3FLHgPKVXJzdDcqLW4N4tpDktz8EMDxdrhtNWdOMn3y+C3QmQ69F7eWBSa4P6zrJGhEF7xh7ei+i;hash|js/qo4AKLr3lepwvVQQuGQ==
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