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dc.contributor.authorNachamkin, Irving
dc.contributor.authorUng, Huong
dc.contributor.authorMoran, Anthony P.
dc.contributor.authorYoo, Dale
dc.contributor.authorPrendergast, Martina M.
dc.contributor.authorNicholson, Mabel A.
dc.contributor.authorSheikh, Kazim
dc.contributor.authorHo, Tony
dc.contributor.authorAsbury, Arthur K.
dc.contributor.authorMcKhann, Guy M.
dc.contributor.authorGriffin, John W.
dc.identifier.citationNachamkin, Irving; Ung, Huong; Moran, Anthony P. Yoo, Dale; Prendergast, Martina M.; Nicholson, Mabel A.; Sheikh, Kazim; Ho, Tony; Asbury, Arthur K.; McKhann, Guy M.; Griffin, John W. (1999). Ganglioside gm1 mimicry incampylobacterstrains from sporadic infections in the united states. The Journal of Infectious Diseases 179 (5), 1183-1189
dc.description.abstractTo determine whether GM1-like epitopes in Campylobacter species are specific to O serotypes associated with Guillain-Barre syndrome (GBS) or whether they are frequent among random Campylobacter isolates causing enteritis, 275 random enteritis-associated isolates of Campylobacter jejuni were analyzed. The isolates were collected in the United States using a cholera toxin-binding assay. Overall, 26.2% of the isolates were positive for the GM1-like epitope. Of the 36 different O serotypes in the sample, 21 (58.3%) contained no strains positive for GM1, whereas in 6 serotypes (16.7%), >50% of isolates were positive for GM1. GBS-associated serotypes were more likely to contain strains positive for GM1 than were non-GBS-associated serotypes (37.8% vs. 15.1%, P = .0116). The results suggest that humans are frequently exposed to strains exhibiting GM1-like mimicry and, while certain serotypes may be more likely to possess GM1-like epitopes, the presence of GM1-like epitopes on Campylobacter strains does not itself trigger GBS.
dc.publisherOxford University Press (OUP)
dc.relation.ispartofThe Journal of Infectious Diseases
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.subjectmotor axonal neuropathy
dc.subjectjejuni infection
dc.subjectmolecular mimicry
dc.subjectchemical structures
dc.subjectnorthern china
dc.subjectcore region
dc.titleGanglioside gm1 mimicry incampylobacterstrains from sporadic infections in the united states

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