Campylobacter jejuni from patients with guillain-barre syndrome preferentially expresses a gd1a-like epitope
Moran, A. P.
Prendergast, M. M.
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Nachamkin, I. Liu, J.; Li, M.; Ung, H.; Moran, A. P.; Prendergast, M. M.; Sheikh, K. (2002). Campylobacter jejuni from patients with guillain-barre syndrome preferentially expresses a gd1a-like epitope. Infection and Immunity 70 (9), 5299-5303
GM(1)- and GD(1a)-like ganglioside mimicry in Campylobacter jejuni lipooligosaccharide (LOS) is considered to be involved in the pathogenesis of Campylobacter-induced Guillain-Barre syndrome (GBS). Compared with gastroenteritis-related isolates, GBS-related C. jejuni isolates were strongly associated with the expression of GDla-like mimicry. The presence of a few genes involved in LOS ganglioside mimicry, cst-II, cgtA, and cgtB, was also associated with GBS-related strains. GDla like epitope expression may be an important virulence phenotype associated with the risk of developing GBS following campylobacter infection.