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dc.contributor.authorMartin, E.D.
dc.contributor.authorGrealy, M.
dc.date.accessioned2018-08-24T08:25:33Z
dc.date.available2018-08-24T08:25:33Z
dc.date.issued2004-11-01
dc.identifier.citationMartin, E.D. Grealy, M. (2004). Plakoglobin expression and localization in zebrafish embryo development. Biochemical Society Transactions 32 , 797-798
dc.identifier.issn0300-5127,1470-8752
dc.identifier.urihttp://hdl.handle.net/10379/9489
dc.description.abstractPlakoglobin (gamma-catenin) and beta-catenin are major components of the adherens junctions and can be localized to the nucleus by activation of the Wnt signalling pathway. In addition, plakoglobin is also found in desmosomes, a vertebrate-specific cell-cell adhesion structure. Plakoglobin expression and localization were examined at the protein level during zebrafish embryonic development by Western blotting and confocal microscopy. Plakoglobin was expressed throughout embryo development at the protein level. Western blotting revealed that embryonic plakoglobin protein content increased between 12- and 24-h post-fertilization (hpf). Confocal microscopy showed that at stages up to 12 hpf, plakoglobin and beta-catenin were co-localized and expressed in both the nucleus and in cell-cell junctions. At 24- and 72-hpf, separate patterns were seen for plakoglobin and S-catenin. These data indicate that plakoglobin localization in the heart region shifts from adherens junctions to desmosomes during heart chamber development.
dc.publisherPortland Press Ltd.
dc.relation.ispartofBiochemical Society Transactions
dc.subjectbeta-catenin
dc.subjectdesmosomes
dc.subjectheart
dc.subjectplakoglobin
dc.subjectzebrafish
dc.subjectdisease
dc.titlePlakoglobin expression and localization in zebrafish embryo development
dc.typeArticle
dc.identifier.doi10.1042/bst0320797
dc.local.publishedsourcehttp://www.biochemsoctrans.org/content/ppbiost/32/5/797.full.pdf
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