Effect of prostate manipulation on the serum levels of complexed prostate-specific antigen and total prostate-specific antigen
MetadataShow full item record
This item's downloads: 0 (view details)
LONG, RONAN; GIRI, SUBHASIS; DIVER, SEAN; DUDDY, LORNA; MCKEOWN, DECLAN; MORAN, KEVIN (2006). Effect of prostate manipulation on the serum levels of complexed prostate-specific antigen and total prostate-specific antigen. International Journal of Urology 13 (7), 947-950
Background: Recently there has been considerable interest in complexed prostate-specific antigen (cPSA) as an alternative to total PSA (tPSA). Data regarding the variations of cPSA are limited. We performed a prospective study using different forms of prostate manipulation to demonstrate and compare variations between cPSA and tPSA. Methods: The study included 113 men, 34 of whom had a digital rectal examination, 28 had a flexible cystoscopy, 17 had a rigid cystoscopy, 21 had a prostate biopsy, and 13 underwent a transurethral resection of the prostate (TURP). Blood samples were taken before and after manipulation for measurement of tPSA and cPSA. Results: There was a statistically significant difference in the cPSA and tPSA before and after manipulation, with the exception of cystoscopy. On review of the data, it was clear that not all changes were clinically significant. The mean differences were greater for tPSA than for cPSA for all procedures. This was most apparent following prostate biopsy and TURP. Regression analysis also showed that cPSA and tPSA were affected differently by prostate manipulation. Conclusion: Our results demonstrate that cPSA is less prone to variations when compared to tPSA.
Showing items related by title, author, creator and subject.
Toner, Aidan (2015-03-31)Prostate cancer remains a growing problem for the male population, globally. Though there have been clinical advances in recent years, there still remains a need to develop drugs that can slow or stop progression beyond ...
Downey, Ronan F.; Sullivan, Francis J.; Wang-Johanning, Feng; Ambs, Stefan; Giles, Francis J.; Glynn, Sharon A. (Wiley-Blackwell, 2014-06-17)Harbored as relics of ancient germline infections, human endogenous retroviruses (HERVs) now constitute up to 8% of our genome. A proportion of this sequence has been co-opted for molecular and cellular processes, beneficial ...
Kadimisetty, Karteek; Mosa, Islam M.; Malla, Spundana; Satterwhite-Warden, Jennifer E.; Kuhns, Tyler M.; Faria, Ronaldo C.; Lee, Norman H.; Rusling, James F. (Elsevier BV, 2016-03-01)