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dc.contributor.authorJohnson, Z.
dc.contributor.authorLillis, D.
dc.contributor.authorDelany, V.
dc.contributor.authorHayes, C.
dc.contributor.authorDack, P.
dc.date.accessioned2018-08-24T08:25:14Z
dc.date.available2018-08-24T08:25:14Z
dc.date.issued1996-03-01
dc.identifier.citationJohnson, Z. Lillis, D.; Delany, V.; Hayes, C.; Dack, P. (1996). The epidemiology of down syndrome in four counties in ireland 1981-1990. Journal of Public Health 18 (1), 78-86
dc.identifier.issn1741-3842,1741-3850
dc.identifier.urihttp://hdl.handle.net/10379/9352
dc.description.abstractBackground We conducted a descriptive epidemiological study oi Down syndrome (DS) in the four Irish counties (Dublin, Kildare, Wicklow and Galway) covered by EUROCAT registries of congenital malformations for the years 1981-1990. Methods EUROCAT registries, which cover defined populations, use multiple sources for case ascertainment Ali DS cases born between 1 January 1981 and 31 December 1990 to mothers resident in the lour counties were identified. Crude birth prevalence rates and maternal age-standardized rates (SPRs) were calculated for each county and for each year in the study period, The prevalence oi DS by maternal age grouped in five-year periods and the risk for each live-year group were also estimated. Results The crude birth prevalence for the :our counties was 18.5/10000 for all births and 18.3 for live births. There was a fall in the total number oi DS births over the decade, but less change in the crude birth prevalence owing to an increase in the proportion oi mothers aged 35 +. Galway had the highest crude birth prevalence of DS (23.5/10000) but the SPR was within average for the lour counties as a whole - 110.3, 95 per cent confidence interval (CI) 86.7-139. The risk oi having a DS child increased 70-fold from 1:1841 at age 15-19 to 1:26 at 45 years or older. Nearly half oi all DS cases (47.4 per cent) had at least one additional anomaly Conclusions The parts oi ireland covered by EUROCAT have a high birth prevalence oi DS births as compared with some other countries, but the maternal age-specific rates are not substantially different from those in large international studies.
dc.publisherOxford University Press (OUP)
dc.relation.ispartofJournal of Public Health
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectdown syndrome
dc.subjectepidemiology
dc.subjectmaternal age
dc.subjectabnormalities
dc.subjectdown-syndrome
dc.titleThe epidemiology of down syndrome in four counties in ireland 1981-1990
dc.typeArticle
dc.identifier.doi10.1093/oxfordjournals.pubmed.a024466
dc.local.publishedsourcehttps://academic.oup.com/jpubhealth/article-pdf/18/1/78/4450273/18-1-78.pdf
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