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dc.contributor.authorHeath, P. T.
dc.contributor.authorBooy, R.
dc.contributor.authorGriffiths, H.
dc.contributor.authorClutterbuck, E.
dc.contributor.authorAzzopardi, H. J.
dc.contributor.authorSlack, M. P. E.
dc.contributor.authorFogarty, J.
dc.contributor.authorMoloney, A. C.
dc.contributor.authorMoxon, E. R.
dc.date.accessioned2018-08-24T08:25:06Z
dc.date.available2018-08-24T08:25:06Z
dc.date.issued2000-10-01
dc.identifier.citationHeath, P. T. Booy, R.; Griffiths, H.; Clutterbuck, E.; Azzopardi, H. J.; Slack, M. P. E.; Fogarty, J.; Moloney, A. C.; Moxon, E. R. (2000). Clinical and immunological risk factors associated withhaemophilus influenzaetype b conjugate vaccine failure in childhood. Clinical Infectious Diseases 31 (4), 973-980
dc.identifier.issn1058-4838,1537-6591
dc.identifier.urihttp://hdl.handle.net/10379/9289
dc.description.abstractHaemophilus influenzae type b (Hib) conjugate vaccines have proved extremely efficacious in healthy children. True Hib vaccine failures are rare. Hib conjugate vaccines were introduced for routine immunization in the United Kingdom and the Republic of Ireland in 1992, Coincident with this, active prospective and national surveillance via pediatricians, microbiologists, and public health physicians was commenced to assess the clinical and immunological factors associated with vaccine failure. During the 6 years of the study, 115 children with true vaccine failure were reported. Of the children who were vaccinated before 12 months of age, a clinical risk factor was detected in 20%, an immunological deficiency was detected in 30%, and one or both were detected in 44%. Children who were vaccinated after 12 months of age were more likely to have one or both factors (67%). Thirty percent (33 of 105) of children with true vaccine failure had a low Hib antibody response (concentration, <1.0 <mu>g/mL) after disease, but the majority then responded to a further dose of Hib vaccine. Children who develop Hib disease despite vaccination deserve further clinical and immunological evaluation.
dc.publisherOxford University Press (OUP)
dc.relation.ispartofClinical Infectious Diseases
dc.subjectcapsular polysaccharide
dc.subjectantibody-response
dc.subjectimmunoglobulin deficiency
dc.subjectaccelerated immunization
dc.subjectprotein conjugate
dc.subjectpreterm infants
dc.subjectdowns-syndrome
dc.subjectchildren
dc.subjectdisease
dc.subjectmeningitis
dc.titleClinical and immunological risk factors associated withhaemophilus influenzaetype b conjugate vaccine failure in childhood
dc.typeArticle
dc.identifier.doi10.1086/318132
dc.local.publishedsourcehttps://academic.oup.com/cid/article-pdf/31/4/973/1072828/31-4-973.pdf
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