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dc.contributor.authorHarmon, D.
dc.contributor.authorRozario, C.
dc.contributor.authorLowe, D.
dc.date.accessioned2018-08-24T08:25:04Z
dc.date.available2018-08-24T08:25:04Z
dc.date.issued2003-02-01
dc.identifier.citationHarmon, D. Rozario, C.; Lowe, D. (2003). Nitrous oxide/oxygen mixture and the prevention of pain during injection of propofol. European Journal of Anaesthesiology 20 (2), 158-161
dc.identifier.issn0265-0215
dc.identifier.urihttp://hdl.handle.net/10379/9272
dc.description.abstractBackground and objective: The incidence of pain associated with the injection of propofol still remains a problem. This study sought to examine the analgesic effects of inhaled nitrous oxide in oxygen on the prevention of propofol injection pain. Methods: Nitrous oxide in oxygen was compared with a lidocaine (20mg)-propofol mixture and with propofol alone (control) in a prospective, randomized, observer-blinded study. ASA I and 11 patients (n = 135) scheduled for elective surgical procedures were studied. A standard propofol injection technique and scoring system to measure the pain on injection was used. Results: Demographic variables were similar between the study groups. Without analgesia (control) 26 of 45 patients (58%) reported pain on injection compared with 11 of 45 patients (24%) in both the nitrous oxide (95% CI: 14-52%, P = 0.001) and lidocaine groups (95% Cl: 14-52%, P = 0.001). Conclusions: The inhalation of a nitrous oxide/oxygen mixture significantly reduces the incidence of pain during propofol injection. This therapeutic stratagem was as effective as a lidocaine-propofol mixture.
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.relation.ispartofEuropean Journal of Anaesthesiology
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectanaesthetics, intravenous, propofol
dc.subjectanaesthetics, local, lidocaine
dc.subjectinorganic chemicals, nitrous oxide
dc.subjectnervous system physiology, sensation, pain
dc.subjectperipheral nervous system agents, sensory system agents
dc.subjectiv injection
dc.subjectoxide
dc.subjectinduction
dc.subjectanesthesia
dc.subjectlignocaine
dc.subjectlidocaine
dc.subjectdiprivan
dc.titleNitrous oxide/oxygen mixture and the prevention of pain during injection of propofol
dc.typeArticle
dc.identifier.doi10.1097/00003643-200302000-00014
dc.local.publishedsourcehttp://pdfs.journals.lww.com/ejanaesthesiology/2003/02000/Nitrous_oxide_oxygen_mixture_and_the_prevention_of.14.pdf?token=method|ExpireAbsolute;source|Journals;ttl|1506765613699;payload|mY8D3u1TCCsNvP5E421JYK6N6XICDamxByyYpaNzk7FKjTaa1Yz22MivkHZqjGP4kdS2v0J76WGAnHACH69s21Csk0OpQi3YbjEMdSoz2UhVybFqQxA7lKwSUlA502zQZr96TQRwhVlocEp/sJ586aVbcBFlltKNKo+tbuMfL73hiPqJliudqs17cHeLcLbV/CqjlP3IO0jGHlHQtJWcICDdAyGJMnpi6RlbEJaRheGeh5z5uvqz3FLHgPKVXJzdGZnEagBFgfcfP0kYnmKqypF9wccgAm7U2UaHvnJhF3Vho90dQXhl158NhZpCNR/f;hash|t8N2g63grY+tnbElRlyKig==
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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