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dc.contributor.authorHarmon, D.
dc.contributor.authorRozario, C.
dc.contributor.authorLowe, D.
dc.identifier.citationHarmon, D. Rozario, C.; Lowe, D. (2003). Nitrous oxide/oxygen mixture and the prevention of pain during injection of propofol. European Journal of Anaesthesiology 20 (2), 158-161
dc.description.abstractBackground and objective: The incidence of pain associated with the injection of propofol still remains a problem. This study sought to examine the analgesic effects of inhaled nitrous oxide in oxygen on the prevention of propofol injection pain. Methods: Nitrous oxide in oxygen was compared with a lidocaine (20mg)-propofol mixture and with propofol alone (control) in a prospective, randomized, observer-blinded study. ASA I and 11 patients (n = 135) scheduled for elective surgical procedures were studied. A standard propofol injection technique and scoring system to measure the pain on injection was used. Results: Demographic variables were similar between the study groups. Without analgesia (control) 26 of 45 patients (58%) reported pain on injection compared with 11 of 45 patients (24%) in both the nitrous oxide (95% CI: 14-52%, P = 0.001) and lidocaine groups (95% Cl: 14-52%, P = 0.001). Conclusions: The inhalation of a nitrous oxide/oxygen mixture significantly reduces the incidence of pain during propofol injection. This therapeutic stratagem was as effective as a lidocaine-propofol mixture.
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.relation.ispartofEuropean Journal of Anaesthesiology
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.subjectanaesthetics, intravenous, propofol
dc.subjectanaesthetics, local, lidocaine
dc.subjectinorganic chemicals, nitrous oxide
dc.subjectnervous system physiology, sensation, pain
dc.subjectperipheral nervous system agents, sensory system agents
dc.subjectiv injection
dc.titleNitrous oxide/oxygen mixture and the prevention of pain during injection of propofol

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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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