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dc.contributor.authorGrealy, M.
dc.contributor.authorO'Donnell, J.M.
dc.date.accessioned2018-08-24T08:24:59Z
dc.date.available2018-08-24T08:24:59Z
dc.date.issued1991-02-01
dc.identifier.citationGrealy, M. O'Donnell, J.M. (1991). Secretion of growth hormone elicited by intravenous desipramine in the conscious, unrestrained rat. British Journal of Pharmacology 102 (2), 369-372
dc.identifier.issn0007-1188
dc.identifier.urihttp://hdl.handle.net/10379/9236
dc.description.abstract1 Acute intravenous administration of either clonidine (Clon) (50-mu-g kg-1) or desipramine (DMI) (5 mg kg-1) elicited a pulse of growth hormone (GH) and corticosterone secretion in conscious, unrestrained rats. 2 The responses to DMI were similar to those with Clon, except that the GH pulse following DMI was delayed and was not dose-dependent. 3 The GH response to DMI was inhibited by prior administration of idazoxan (1 mg kg-1) or yohimbine (0.5 mg kg-1), but not by atropine (10-mu-g kg-1), sulpiride (5 mg kg-1) or prazosin (1 mg kg-1). 4 The corticosterone secretion following DMI was not altered by prior atropine, sulpiride or prazosin, but was augmented by idazoxan (1 mg kg-1). 5 GH secretion was not influenced by atropine, sulpiride, prazosin or idazoxan given alone. Idazoxan or yohimbine given alone elicited significant secretion of corticosterone. 6 It is concluded that i.v. DMI caused an activation through indirect mechanisms of alpha-2-adrenoceptors specifically involved in hypothalamic-pituitary regulation of GH release and also a distinct, independent and transient generalized activation of the pituitary-adrenal axis.
dc.publisherWiley-Blackwell
dc.relation.ispartofBritish Journal of Pharmacology
dc.subjectclonidine
dc.subjectreserpine
dc.subjectreceptors
dc.titleSecretion of growth hormone elicited by intravenous desipramine in the conscious, unrestrained rat
dc.typeArticle
dc.identifier.doi10.1111/j.1476-5381.1991.tb12180.x
dc.local.publishedsourcehttp://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.1991.tb12180.x/pdf
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