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    Secretion of growth hormone elicited by intravenous desipramine in the conscious, unrestrained rat

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    Date
    1991-02-01
    Author
    Grealy, M.
    O'Donnell, J.M.
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    Cited 22 times in Scopus (view citations)
    
    Recommended Citation
    Grealy, M. O'Donnell, J.M. (1991). Secretion of growth hormone elicited by intravenous desipramine in the conscious, unrestrained rat. British Journal of Pharmacology 102 (2), 369-372
    Published Version
    http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.1991.tb12180.x/pdf
    Abstract
    1 Acute intravenous administration of either clonidine (Clon) (50-mu-g kg-1) or desipramine (DMI) (5 mg kg-1) elicited a pulse of growth hormone (GH) and corticosterone secretion in conscious, unrestrained rats. 2 The responses to DMI were similar to those with Clon, except that the GH pulse following DMI was delayed and was not dose-dependent. 3 The GH response to DMI was inhibited by prior administration of idazoxan (1 mg kg-1) or yohimbine (0.5 mg kg-1), but not by atropine (10-mu-g kg-1), sulpiride (5 mg kg-1) or prazosin (1 mg kg-1). 4 The corticosterone secretion following DMI was not altered by prior atropine, sulpiride or prazosin, but was augmented by idazoxan (1 mg kg-1). 5 GH secretion was not influenced by atropine, sulpiride, prazosin or idazoxan given alone. Idazoxan or yohimbine given alone elicited significant secretion of corticosterone. 6 It is concluded that i.v. DMI caused an activation through indirect mechanisms of alpha-2-adrenoceptors specifically involved in hypothalamic-pituitary regulation of GH release and also a distinct, independent and transient generalized activation of the pituitary-adrenal axis.
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    http://hdl.handle.net/10379/9236
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