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dc.contributor.authorDavis, George H.
dc.contributor.authorGalloway, Susan M.
dc.contributor.authorRoss, Ian K.
dc.contributor.authorGregan, Scott M.
dc.contributor.authorWard, Jamie
dc.contributor.authorNimbkar, Bon V.
dc.contributor.authorGhalsasi, Pradip M.
dc.contributor.authorNimbkar, Chanda
dc.contributor.authorGray, G. Douglas
dc.contributor.authorSubandriyo,
dc.contributor.authorInounu, Ismeth
dc.contributor.authorTiesnamurti, Bess
dc.contributor.authorMartyniuk, Elzbieta
dc.contributor.authorEythorsdottir, Emma
dc.contributor.authorMulsant, Philippe
dc.contributor.authorLecerf, Frederic
dc.contributor.authorHanrahan, James P.
dc.contributor.authorBradford, G. Eric
dc.contributor.authorWilson, Theresa
dc.date.accessioned2018-08-24T08:24:33Z
dc.date.available2018-08-24T08:24:33Z
dc.date.issued2002-06-01
dc.identifier.citationDavis, George H. Galloway, Susan M.; Ross, Ian K.; Gregan, Scott M.; Ward, Jamie; Nimbkar, Bon V.; Ghalsasi, Pradip M.; Nimbkar, Chanda; Gray, G. Douglas; Subandriyo, ; Inounu, Ismeth; Tiesnamurti, Bess; Martyniuk, Elzbieta; Eythorsdottir, Emma; Mulsant, Philippe; Lecerf, Frederic; Hanrahan, James P.; Bradford, G. Eric; Wilson, Theresa (2002). Dna tests in prolific sheep from eight countries provide new evidence on origin of the booroola (fecb) mutation1. Biology of Reproduction 66 (6), 1869-1874
dc.identifier.issn0006-3363,1529-7268
dc.identifier.urihttp://hdl.handle.net/10379/9043
dc.description.abstractRecent discoveries that high prolificacy in sheep carrying the Booroola gene (FecB) is the result of a mutation in the BMPIB receptor and high prolificacy in Inverdale sheep (FecX(1)) is the result of a mutation in the BMP15 oocyte-derived growth factor gene have allowed direct marker tests to be developed for FecB and FecX(1). These tests were carried out in seven strains of sheep (Javanese, Thoka, Woodlands, Olkuska, Lacaune, Belclare, and Cambridge) in which inheritance patterns have suggested the presence of major genes affecting prolificacy and in the prolific Garole sheep of India, which have been proposed as the ancestor of Australian Booroola Merinos. The FecB mutation was found in the Garole and Javanese sheep but not in Thoka, Woodlands, Olkuska, Lacaune, Belclare, and Cambridge sheep. None of the sheep tested had the FecX1 mutation. These findings present strong evidence to support historical records that the Booroola gene was introduced into Australian flocks from Garole (Bengal) sheep in the late 18th century. It is unknown whether Javanese Thin-tailed sheep acquired the Booroola gene directly from Garole sheep from India or via Merinos from Australia. The DNA mutation test for FecB will enable breeding plans to be developed that allow the most effective use of this gene in Garole and Javanese Thin-tailed sheep and their crosses.
dc.publisherOxford University Press (OUP)
dc.relation.ispartofBiology of Reproduction
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectgene regulation
dc.subjectovary ovulation
dc.subjectincreased ovulation rate
dc.subjectx-chromosome
dc.subjectgene
dc.subjectewes
dc.subjectinfertility
dc.subjectfecundity
dc.subjectib
dc.titleDna tests in prolific sheep from eight countries provide new evidence on origin of the booroola (fecb) mutation1
dc.typeArticle
dc.identifier.doi10.1095/biolreprod66.6.1869
dc.local.publishedsourcehttps://academic.oup.com/biolreprod/article-pdf/66/6/1869/10647941/biolreprod1869.pdf
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