dc.contributor.author | Darcy, Philip | |
dc.contributor.author | Dredge, Keith | |
dc.contributor.author | Kellehir, Padraig | |
dc.contributor.author | Kelly, John P. | |
dc.contributor.author | Leonard, Brian E. | |
dc.contributor.author | Chambers, Philip L. | |
dc.date.accessioned | 2018-08-24T08:24:32Z | |
dc.date.available | 2018-08-24T08:24:32Z | |
dc.date.issued | 1999-10-01 | |
dc.identifier.citation | Darcy, Philip; Dredge, Keith; Kellehir, Padraig; Kelly, John P. Leonard, Brian E.; Chambers, Philip L. (1999). Acute toxicity profile of maprotiline in the rat. Pharmacology & Toxicology 85 (6), 276-281 | |
dc.identifier.issn | 0901-9928,1600-0773 | |
dc.identifier.uri | http://hdl.handle.net/10379/9039 | |
dc.description.abstract | The aim of the present study was to examine the toxic effects of single oral administrations of the antidepressant maprotiline at 150 mg/kg or 300 mg/kg using female Sprague-Dawley rats. Body-weight gain was significantly reduced in the group receiving 300 mg/kg on days 1-5 of the study (P<0.01). A significant reduction in food and water intake was observed on days 1 and 2 of the study (P<0.01) in the 300 mg/kg group and on day 1 in the 150 mg/kg group (P<0.05). There was a significant decrease in nocturnal home cage activity over the first five days of the study in the 300 mg/kg group (P<0.01). A significant hypothermic response was observed in both 150 and 300 mg/kg groups at 1, 2 and 4 hr after dosing (P<0.01), that had returned to control values within 8 hr following administration. This study demonstrates that a multi-parameter approach is appropriate for the investigation of high doses of antidepressants in rodents. | |
dc.publisher | Wiley-Blackwell | |
dc.relation.ispartof | Pharmacology & Toxicology | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | antidepressant drugs | |
dc.subject | suicide | |
dc.subject | overdose | |
dc.title | Acute toxicity profile of maprotiline in the rat | |
dc.type | Article | |
dc.identifier.doi | 10.1111/j.1600-0773.1999.tb02022.x | |
dc.local.publishedsource | http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0773.1999.tb02022.x/pdf | |
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