National Centre for Biomedical Engineering Science (Scholarly Articles): Recent submissions
Now showing items 21-40 of 79
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Predicting the elastic properties of selective laser sintered PCL/b-TCP bone scaffold materials using computational modelling.
(Springer, 2013)Abstract This study assesses the ability of finite element (FE) models to capture the mechanical behaviour of sintered orthopaedic scaffold materials. Individual scaffold struts were fabricated from a 50:50 wt% ... -
Laser sintering for the fabrication of tissue engineering scaffolds
(Springer Science+Business Media, 2012)Laser sintering (LS) utilises a laser to sinter powder particles. A volumetric model is sliced and processedcross section by cross section to create a physical part. In theory, all powdered materials are suitable forsintering; ... -
Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint
(Company of Biologists, 2016)During mitotic arrest induced by microtubule targeting drugs, the weakening of the spindle assembly checkpoint (SAC) allows cells to progress through the cell cycle without chromosome segregation occurring. PLK1 kinase ... -
Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells
(2015)Endoplasmic reticulum (ER) stress-induced cellular dysfunction and death is associated with several human diseases. It has been widely reported that ER stress kills through activation of the intrinsic mitochondrial apoptotic ... -
miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts
(2014)Background: Glucose and oxygen deprivation during ischemia is known to affect the homeostasis of the endoplasmic reticulum (ER) in ways predicted to activate the unfolded protein response (UPR). Activation of UPR signalling ... -
Disruption of microRNA Biogenesis Confers Resistance to ER Stress-Induced Cell Death Upstream of the Mitochondrion
(2013)Global downregulation of microRNAs (miRNAs) is a common feature of human tumors and has been shown to enhance cancer progression. Several components of the miRNA biogenesis machinery (XPO5, DICER and TRBP) have been shown ... -
Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways
(2013)Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine and a selective inducer of apoptosis in a range of tumour cells, but not in normal, untransformed cells. A large number of chemotherapeutics ... -
Characterisation of the differentially regulated trout protein 1 (DRTP1) gene in rainbow trout (Oncorhynchus mykiss)
(Elsevier, 2008-10-04)Increased levels of differentially regulated trout protein 1 (DRTP1) mRNA transcripts have been reported in fish after activation of the acute phase response. While the function of the DRTP1 protein still remains to be ... -
Acute phase gene expression in rainbow trout (Oncorhynchus mykiss) after exposure to a confinement stressor: A comparison of pooled and individual data
(Elsevier, 2009-06-09)This study set out to investigate whether differential expression of genes for acute phase proteins in rainbow trout (Oncorhynchus mykiss) could be induced by confinement stress, a non-invasive method of activating the ... -
Testes and brain gene expression in precocious male and adult maturing Atlantic salmon (Salmo salar)
(BioMed Central, 2010)Background: The male Atlantic salmon generally matures in fresh water upon returning after one or several years at sea. Some fast-growing male parr develop an alternative life strategy where they sexually mature before ... -
Solvent-selective routing for centrifugally automated solid-phase purification of RNA.
(Springer, 2014-09-12)We present a disc-based module for rotationally controlled solid-phase purification of RNA from cell lysate. To this end, multi-stage routing of a sequence of aqueous and organic liquids into designated waste and elution ... -
Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design
(National Academy Of Sciences Of The United States Of America, 2013-10-23)Cyclotides are plant peptides comprising a circular backbone and three conserved disulfide bonds that confer them with exceptional stability. They were originally discovered in Oldenlandia affinis based on their use in ... -
Rho A/Rho kinase: human umbilical artery mRNA expression in normal and pre eclamptic pregnancies and functional role in isoprostane-induced vasoconstriction
(Society for Reproduction and Fertility, 2006-07-01)Pre eclampsia represents a state of increased or prolonged vasoconstriction, partially linked to the potent vasocontractile effect of isoprostanes. The process of Rho A-mediated calcium sensitisation is inherent to a state ... -
Effects of long-term exposure of gelatinated and non-gelatinated cadmium telluride quantum dots on differentiated PC12 cells
(BioMed Central, 2012-01-20)Background: The inherent toxicity of unmodified Quantum Dots (QDs) is a major hindrance to their use in biological applications. To make them more potent as neuroprosthetic and neurotherapeutic agents, thioglycolic acid ... -
Functional coupling of beta(3)-adrenoceptors and large conductance calcium-activated potassium channels in human uterine myocytes
(Endocrine Society, 2005-07-02)Context: beta(3)-Adrenoreceptor modulation in human myometrium during pregnancy is linked functionally to myometrial inhibition. Maxi-K+ channels (BKCa) play a significant role in modulating cell membrane potential and ... -
Transcription factor binding site identification using the Self-Organizing Map
(Oxford Open Journals, 2005-05-01)Motivation: The automatic identification of over-represented motifs present in a collection of sequences continues to be a challenging problem in computational biology. In this paper, we propose a self-organizing map of ... -
Gene prediction using the Self-Organizing Map: automatic generation of multiple gene models
(2004-03-05)This work explores a new approach to gene-prediction, based on the Self-Organizing Map, which has the ability to automatically identify multiple gene models within a genome. The current implementation, named RescueNet, ... -
Evaluation of a novel PCR based diagnostic assay for the detection of Mycobacterium tuberculosis in sputum specimens
(ACM, 1996-06-18)We report on a PCR-based assay we have developed for the detection of Mycobacterium tuberculosis in sputum samples. One hundred sputum specimens, which included 34 culture-positive and 66 culture-negative specimens, were ... -
Mesenchymal stem cells and osteoarthritis: remedy or accomplice?
(Mary Ann Liebert, Inc., 2010-10)Multipotent mesenchymal stromal or stem cells (MSCs) are likely to be agents of connective tissue homeostasis and repair. Because the hallmark of osteoarthritis (OA) is degeneration and failure to repair connective tissues ...