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Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design
(National Academy Of Sciences Of The United States Of America, 2013-10-23)
Cyclotides are plant peptides comprising a circular backbone and three conserved disulfide bonds that confer them with exceptional stability. They were originally discovered in Oldenlandia affinis based on their use in ...
Testes and brain gene expression in precocious male and adult maturing Atlantic salmon (Salmo salar)
(BioMed Central, 2010)
Background: The male Atlantic salmon generally matures in fresh water upon returning after one or several years at sea. Some fast-growing male parr develop an alternative life strategy where they sexually mature before ...
DNA mediated chromatin pull-down for the study of chromatin replication
(2011)
Chromatin replication involves duplicating DNA while maintaining epigenetic information. These processes are critical for genome stability and for preserving cell-type identity. Here we describe a simple experimental ...
Mesenchymal stem cells and osteoarthritis: remedy or accomplice?
(Mary Ann Liebert, Inc., 2010-10)
Multipotent mesenchymal stromal or stem cells (MSCs) are likely to be agents of connective tissue homeostasis and repair. Because the hallmark of osteoarthritis (OA) is degeneration and failure to repair connective tissues ...
Construction of a Natural Mucin Microarray and Interrogation for Biologically Relevant Glyco-Epitopes
(2012)
Mucins are the principal components of mucus, and mucin glycosylation has important roles in defense, microbial adhesion, immunomodulation, inflammation, and cancer. Mucin expression and glycosylation are dynamic, responding ...
Neuronal glycosylation differentials in normal, injured and chondroitinase-treated environments
(2012)
Glycosylation is found ubiquitously throughout the central nervous system (CNS). Chondroitin sulphate proteoglycans (CSPGs) are a group of molecules heavily substituted with glycosaminoglycans (GAGs) and are found in the ...
Periodic acid-Schiff's reagent assay for carbohydrates in a microtiter plate format
(2011)
Microtiter plate colorimetric assays are widely used for analysis of carbohydrates and glycoconjugates. However, mucins are often not easily detected, as they have low neutral sugar content. We have adapted and optimised ...
Differential release of high mannose structural isoforms by fungal and bacterial endo-β-N-acetylglucosaminidases
(Royal Society of Chemistry, 2012-02-28)
Endo-beta-N-acetylglucosaminidases (ENGases) are widely used to remove N-linked oligosaccharides from glycoproteins for glycomic and proteomic studies and biopharmaceutical processes. Although several ENGases are widely ...
Campylobacter jejuni strain discrimination and temperature-dependent glycome expression profiling by lectin microarray
(Elsevier, 2014-02-12)
Gram-negative Campylobacter jejuni is the leading cause of bacterial gastroenteritis in humans worldwide and the most frequently identified infectious trigger in patients developing Guillain-Barré syndrome (GBS). While ...
Use of microarray technology to assess the time course of liver stress response after confinement exposure in gilthead sea bream (Sparus aurata L.)
(BioMed Central, 2010-03-22)
Background: Selection programs for growth and stress traits in cultured fish are fundamental to the improvement of aquaculture production. The gilthead sea bream ( Sparus aurata) is the main aquacultured species in the ...