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dc.contributor.authorMcDermott, Barry
dc.contributor.authorPorter, Emily
dc.contributor.authorHughes, Diarmaid
dc.contributor.authorMcAuley, Brian
dc.contributor.authorLang, Mark
dc.contributor.authorO'Halloran, Martin
dc.contributor.authorJones, Marggie
dc.date.accessioned2018-08-20T11:10:40Z
dc.date.available2018-08-20T11:10:40Z
dc.date.issued2018-07-19
dc.identifier.citationMcDermott, Barry, Porter, Emily, Hughes, Diarmaid, McAuley, Brian, Lang, Mark, O'Halloran, Martin, & Jones, Marggie. (2018). Gamma Band Neural Stimulation in Humans and the Promise of a New Modality to Prevent and Treat Alzheimer's Disease'. Journal of Alzheimer's Disease, 1-30. doi: 10.3233/JAD-180391en_IE
dc.identifier.issn1387-2877
dc.identifier.urihttp://hdl.handle.net/10379/7515
dc.description.abstractExisting treatments for Alzheimer s Disease have questionable efficacy with a need for research into new and more effective therapies to both treat and possibly prevent the condition. This review examines a novel therapeutic modality that shows promise for treating Alzheimer s Disease based on modulating neuronal activity in the gamma frequency band through external brain stimulation. The gamma frequency band is roughly defined as being between 30 Hz - 100 Hz, with the 40 Hz point being of particular significance. The epidemiology, diagnostics, existing pathological models, and related current treatment targets are initially briefly reviewed. Next, the concept of external simulation triggering brain activity in the gamma band with potential demonstration of benefit in Alzheimer s is introduced with reference to a recent important study using a mouse model of the disease. The review then presents a selection of relevant studies that describe the neurophysiology involved in brain stimulation by external sources, followed by studies involving application of the modality to clinical scenarios. A table summarizing the results of clinical studies applied to Alzheimer s patients is also reported and may aid future development of the modality. The use of a therapy based on modulation of gamma neuronal activity represents a novel non-invasive, non-pharmacological approach to Alzheimer s Disease. Although use in clinical scenarios is still a relatively recent area of research, the technique shows good signs of efficacy and may represent an important option for treating Alzheimer s Disease in the future.en_IE
dc.description.sponsorshipThe research leading to these results has received funding from the European Research Council under the European Union’s Horizon 2020 Programme/ ERC Grant Agreement BioElecPro n.637780, Science Foundation Ireland (SFI) grant number 15/ERCS/3276, the Hardiman Research Scholarship from NUIG, the charity RESPECT and the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA Grant Agreement no. PCOFUND-GA-2013-608728.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherIOS Pressen_IE
dc.relation.ispartofJournal Of Alzheimers Diseaseen
dc.subject40 Hzen_IE
dc.subjectAlzheimer s diseaseen_IE
dc.subjectgammaen_IE
dc.subjectneural stimulationen_IE
dc.titleGamma band neural stimulation in humans and the promise of a new modality to prevent and treat Alzheimer's diseaseen_IE
dc.typeArticleen_IE
dc.date.updated2018-08-15T17:25:31Z
dc.identifier.doi10.3233/JAD-180391
dc.local.publishedsourcehttps://dx.doi.org/10.3233/JAD-180391en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderEuropean Research Councilen_IE
dc.contributor.funderScience Foundation Irelanden_IE
dc.contributor.funderHorizon 2020en_IE
dc.contributor.funderHardiman Research Scholarship, NUI Galwayen_IE
dc.contributor.funderFP7 People: Marie-Curie Actionsen_IE
dc.contributor.funderRESPECTen_IE
dc.internal.rssid14792807
dc.local.contactBarry Mc Dermott, Translational Medical Device Lab, , 2nd Floor Lambe Translational Research Facility,, University College Hospital, , Galway. - Email: b.mcdermott3@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI ERC Support Programme/15/ERCS/3276/IE/BIOELECPRO: Frontier Research on the Dielectric Properties of Biological Tissue/en_IE
dcterms.projectinfo:eu-repo/grantAgreement/EC/H2020::ERC::ERC-STG/637780/EU/Frontier Research on the Dielectric Properties of Biological Tissue/BIOELECPROen_IE
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