Trends in the incidence and outcomes of end stage kidney disease from specific causes and the ability of measures of kidney function to predict mortality in community dwelling individuals

Abstract

Summary of Contents There are two broad themes in this research thesis. The first is an exploration of the ability of measures of kidney function and urinary protein excretion to predict death based on non-parametric methodology known as classification tree recursive partitioning. In the second part of the thesis, the clinical epidemiology of kidney failure from various rare diseases is characterised including trends in incidence, mortality and kidney transplant in the United States based on national registry data.