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dc.contributor.authorCabral, Joana
dc.contributor.authorRyan, Aideen E.
dc.contributor.authorGriffin, Matthew D.
dc.contributor.authorRitter, Thomas
dc.identifier.citationCabral, Joana, Ryan, Aideen E., Griffin, Matthew D., & Ritter, Thomas. (2018). Extracellular vesicles as modulators of wound healing. Advanced Drug Delivery Reviews. doi:
dc.description.abstractImpaired healing of cutaneous wounds and ulcers continues to have a major impact on the quality of life of millions of people. In recent years, the capacity for stem and progenitor cells to promote wound repair has been investigated with evidence that secreted factors are responsible for the observed therapeutic benefits. This review addresses current evidence in support of stem/progenitor cell-derived extracellular vesicles (EVs) as a regenerative therapy for acceleration of wound healing. Encouraging results for local or systemic administration of EVs have been reported in a range of clinically-relevant animal models of cutaneous wounds. Furthermore, a number of plausible mechanisms involving EV-mediated transfer of proteins and RNAs that trigger pro-repair pathways in target cells have been demonstrated experimentally. However, for successful clinical translation in the coming years, further emphasis on standardized experimental protocols, detailed methodological reporting and clear definition of EV-based therapeutic products will be required.en_IE
dc.description.sponsorshipThis work is supported by Science Foundation Ireland (12/IA/1624 to TR), Health Research Board of Ireland (HRA_POR/2013/341 to TR and MDG) and by a grant from the European Commission (FP7 Collaborative Health Project VISICORT (grant number 602470, to MDG and TR) and by infrastructural funds from the European Regional Development Fund (MDG and TR). The authors have also received support from the PhD program “Molecular and Cellular Mechanisms Underlying Inflammatory Processes” which was funded by the Higher Education Authority of Ireland under Cycle 5 of the Irish Government's Programme for Research in Third Level Institutions (MDG and JC) and from Science Foundation Ireland Centre Grants [REMEDI Strategic Research Cluster (grant number 09/SRC-B1794, AER, MDG, TR) and CÚRAM Research Centre (grant number 13/RC/2073 (MDG and JC)). AER is supported by Science Foundation Ireland (15/SIRG/3456) and an Irish Cancer Society Fellowship (CRF12RYA).en_IE
dc.relation.ispartofAdvanced Drug Delivery Reviewsen
dc.subjectIntercellular communicationen_IE
dc.subjectScar formationen_IE
dc.titleExtracellular vesicles as modulators of wound healingen_IE
dc.contributor.funderScience Foundation Irelanden_IE
dc.contributor.funderHealth Research Boarden_IE
dc.contributor.funderEuropean Commissionen_IE
dc.contributor.funderEuropean Regional Development Funden_IE
dc.local.contactThomas Ritter, School Of Medicine, Regenerative Medicine Institute, Biosciences, Dangan. 5329 Email:
dcterms.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::HEALTH/602470/EU/Adverse Immune Signatures and their Prevention in Corneal Transplantation/VISICORTen_IE
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Investigator Programme/12/IA/1624/IE/Novel therapeutic approaches to improve corneal allograft survival by cell and gene therapy and insights into the mechanism of action/
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Strategic Research Cluster Supplement/09/SRC/B1794s1/IE/SRC REMEDI: Supplement to support Chair in Stem Cell Biology/
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/13/RC/2073/IE/C�RAM - Centre for Research in Medical Devices/
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Starting Investigator Research Grant (SIRG)/15/SIRG/3456/IE/'RESTRAIN' Investigation of tumour stromal interactions in metastatic colon cancer for the identification of novel immuno-therapeutic targets/

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