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A Cu(II) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights

dc.contributor.authorMontagner, D.
dc.contributor.authorFresch, B.
dc.contributor.authorBrowne, K.
dc.contributor.authorGandin, V.
dc.contributor.authorErxleben, Andrea
dc.date.accessioned2018-03-13T15:16:41Z
dc.date.available2018-03-13T15:16:41Z
dc.date.issued2016-12-01
dc.identifier.citationMontagner, D., Fresch, B., Browne, K., Gandin, V., & Erxleben, A. (2017). A Cu(ii) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights. Chemical Communications, 53(1), 134-137. doi: 10.1039/C6CC08100Ben_IE
dc.identifier.issn1364-548X
dc.identifier.urihttp://hdl.handle.net/10379/7199
dc.description.abstractA new Cu-based anticancer metallodrug which targets the translocator protein is reported. [CuBr2(TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug resistant cell lines and induces a 98% reduction of tumor mass in a murine tumor model. Target binding was studied by experimental and computational methods.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherRoyal Society of Chemistryen_IE
dc.relation.ispartofChemical Communicationsen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectPERIPHERAL BENZODIAZEPINE-RECEPTORen_IE
dc.subjectSELECTIVE LIGANDSen_IE
dc.subjectBINDING-AFFINITYen_IE
dc.subject18 KDAen_IE
dc.subjectTSPOen_IE
dc.subjectCANCERen_IE
dc.subjectSITESen_IE
dc.subjectMODELen_IE
dc.titleA Cu(II) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insightsen_IE
dc.typeArticleen_IE
dc.date.updated2018-03-09T13:04:26Z
dc.identifier.doi10.1039/c6cc08100b
dc.local.publishedsourcehttp://dx.doi.org/10.1039/c6cc08100ben_IE
dc.description.peer-reviewedpeer-reviewed
dc.internal.rssid12073168
dc.local.contactAndrea Erxleben, School Of Chemistry, Room 150, Arts/Science Building, Nui Galway. 2483 Email: andrea.erxleben@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionACCEPTED
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland