A Cu(II) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights
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Montagner, D., Fresch, B., Browne, K., Gandin, V., & Erxleben, A. (2017). A Cu(ii) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights. Chemical Communications, 53(1), 134-137. doi: 10.1039/C6CC08100B
A new Cu-based anticancer metallodrug which targets the translocator protein is reported. [CuBr2(TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug resistant cell lines and induces a 98% reduction of tumor mass in a murine tumor model. Target binding was studied by experimental and computational methods.