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dc.contributor.authorAlmotairy, Awatif Rashed Z.
dc.contributor.authorGandin, Valentina
dc.contributor.authorMorrison, Liam
dc.contributor.authorMarzano, Cristina
dc.contributor.authorMontagner, Diego
dc.contributor.authorErxleben, Andrea
dc.date.accessioned2018-03-13T09:39:52Z
dc.date.issued2017-09-10
dc.identifier.citationAlmotairy, Awatif Rashed Z., Gandin, Valentina, Morrison, Liam, Marzano, Cristina, Montagner, Diego, & Erxleben, Andrea. (2017). Antitumor platinum(IV) derivatives of carboplatin and the histone deacetylase inhibitor 4-phenylbutyric acid. Journal of Inorganic Biochemistry, 177, 1-7. doi: https://doi.org/10.1016/j.jinorgbio.2017.09.009en_IE
dc.identifier.issn1873-3344
dc.identifier.urihttp://hdl.handle.net/10379/7196
dc.description.abstractFive new platinum(IV) derivatives of carboplatin each incorporating the histone deacetylase inhibitor 4-phenylbutyrate in axial position were synthesized and characterized by 1H and 195Pt NMR spectroscopy, electrospray ionization mass spectrometry and elemental analysis, namely cis,trans-[Pt(CBDCA)(NH3)2(PBA)(OH)] (1), cis,trans-[Pt(CBDCA)(NH3)2(PBA)2] (2), cis,trans-[Pt(CBDCA)(NH3)2(PBA)(bz)] (3), cis,trans-[Pt(CBDCA)(NH3)2(PBA)(suc)] (4) and cis,trans-[Pt(CBDCA)(NH3)2)(PBA)(ac)] (5) (PBA = 4-phenylbutyrate, CBDCA = 1,1-cyclobutane dicarboxylate, bz = benzoate, suc = succinate and ac = acetate). The reduction behavior in the presence of ascorbic acid was studied by high performance liquid chromatography. The cytotoxicity against a panel of human tumor cell lines, histone deacetylase (HDAC) inhibitory activity, cellular accumulation and the ability to induce apoptosis were evaluated. The most effective complex, compound 3, was found to be up to ten times more effective than carboplatin and to decrease cellular basal HDAC activity by approximately 18% in A431 human cervical cancer cells.en_IE
dc.description.sponsorshipA.A. acknowledges the Royal Embassy of Saudi Arabia Ministry of Education for a Saudi Arabia Government Scholarship. V.G. and C.M. acknowledge the University of Padova (grants 60A04-0443, 60A04-3189 and 60A04-4015/15, DOR2016).en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofJ. Inorg. Biochemen
dc.subjectAnticanceren_IE
dc.subjectCarboplatinen_IE
dc.subjectHistone deacetylase inhibitoren_IE
dc.subject4-Phenylbutyric aciden_IE
dc.subjectPlatinum(IV)en_IE
dc.titleAntitumor platinum(IV) derivatives of carboplatin and the histone deacetylase inhibitor 4-phenylbutyric aciden_IE
dc.typeArticleen_IE
dc.date.updated2018-03-09T13:07:43Z
dc.identifier.doi10.1016/j.jinorgbio.2017.09.009
dc.local.publishedsourcehttps://doi.org/10.1016/j.jinorgbio.2017.09.009en_IE
dc.description.peer-reviewedpeer-reviewed
dc.description.embargo2019-09-10
dc.internal.rssid13291538
dc.local.contactAndrea Erxleben, School Of Chemistry, Room 150, Arts/Science Building, Nui Galway. 2483 Email: andrea.erxleben@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionACCEPTED
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