dc.contributor.author | Gniado, Katarzyna | |
dc.contributor.author | MacFhionnghaile, Pól | |
dc.contributor.author | McArdle, Patrick | |
dc.contributor.author | Erxleben, Andrea | |
dc.date.accessioned | 2018-03-12T11:49:08Z | |
dc.date.issued | 2018-10-28 | |
dc.identifier.citation | Gniado, Katarzyna, MacFhionnghaile, Pól, McArdle, Patrick, & Erxleben, Andrea. (2018). The natural bile acid surfactant sodium taurocholate (NaTC) as a coformer in coamorphous systems: Enhanced physical stability and dissolution behavior of coamorphous drug-NaTc systems. International Journal of Pharmaceutics, 535(1), 132-139. doi: https://doi.org/10.1016/j.ijpharm.2017.10.049 | en_IE |
dc.identifier.issn | 1873-3476 | |
dc.identifier.uri | http://hdl.handle.net/10379/7192 | |
dc.description.abstract | The amorphization of 18 different drugs on milling with one mole equivalent sodium taurocholate (NaTC) was investigated. In all cases the X-ray powder pattern showed an amorphous halo after milling at room temperature or after cryomilling and 14 of the 18 coamorphous drug-NaTC systems were physically stable for between one to eleven months under ambient storage conditions. In three cases, namely carbamazepine-NaTC, indomethacin-NaTC and mefenamic acid-NaTC, significant dissolution advantages over the crystalline drugs were observed, both for the freshly prepared samples and after storage for seven months. To understand the increased physical stability, infrared-, near-infrared and Raman spectroscopic studies were carried out. The effectiveness of NaTC as a coformer in a diverse range of coamorphous systems is attributed to its awkward molecular shape that hampers recrystallization and phase separation and its propensity to form a range of similar, yet different drug-coformer hydrogen bonding arrangements. | en_IE |
dc.description.sponsorship | This work was supported by Science Foundation Ireland under
Grant No. [12/RC/2275] as part of the Synthesis and Solid State
Pharmaceutical Centre (SSPC). | en_IE |
dc.format | application/pdf | en_IE |
dc.language.iso | en | en_IE |
dc.publisher | Elsevier | en_IE |
dc.relation.ispartof | International Journal Of Pharmaceutics | en |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | Amorphous | en_IE |
dc.subject | Crystallization inhibition | en_IE |
dc.subject | Dissolution studies | en_IE |
dc.subject | Spectroscopy | en_IE |
dc.subject | CO-AMORPHOUS SIMVASTATIN | en_IE |
dc.subject | CITRIC-ACID | en_IE |
dc.subject | MECHANICAL ACTIVATION | en_IE |
dc.subject | CRYSTAL-STRUCTURES | en_IE |
dc.subject | SOLID DISPERSIONS | en_IE |
dc.subject | BINARY-SYSTEMS | en_IE |
dc.subject | AMINO-ACIDS | en_IE |
dc.subject | INDOMETHACIN | en_IE |
dc.subject | STATE | en_IE |
dc.subject | FORMULATIONS | en_IE |
dc.title | The natural bile acid surfactant sodium taurocholate (NaTC) as a coformer in coamorphous systems: Enhanced physical stability and dissolution behavior of coamorphous drug-NaTc systems | en_IE |
dc.type | Article | en_IE |
dc.date.updated | 2018-03-09T13:02:52Z | |
dc.identifier.doi | 10.1016/j.ijpharm.2017.10.049 | |
dc.local.publishedsource | https://doi.org/10.1016/j.ijpharm.2017.10.049 | en_IE |
dc.description.peer-reviewed | peer-reviewed | |
dc.contributor.funder | Science Foundation Ireland | en_IE |
dc.description.embargo | 2019-10-28 | |
dc.internal.rssid | 13822892 | |
dc.local.contact | Andrea Erxleben, School Of Chemistry, Room 150, Arts/Science Building, Nui Galway. 2483 Email: andrea.erxleben@nuigalway.ie | |
dc.local.copyrightchecked | No | |
dc.local.version | ACCEPTED | |
dcterms.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2275/IE/Synthesis and Solid State Pharmaceutical Centre (SSPC)/ | en_IE |
nui.item.downloads | 469 | |