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    Author
    Alexandrov, Sergey (10)
    Leahy, Martin (6)McGrath, James (4)Hogan, Josh (3)Subhash, Hrebesh (3)... View MoreSubjectPhysics (4)Optical coherence tomography (3)Microscopy (2)Optical imaging (2)Spatial resolution (2)... View MoreDate Issued2019 (3)2018 (1)2016 (1)2015 (1)2014 (3)TypeArticle (8)Conference Paper (2)

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    Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation 

    Uttam, Shikhar; Bista, Rajan K.; Staton, Kevin; Alexandrov, Sergey; Choi, Serah; Bakkenist, Christopher J.; Hartman, Douglas J.; Brand, Randall E.; Liu, Yang (2013)
    We present depth-resolved spatial-domain low-coherence quantitative phase microscopy, a simple approach that utilizes coherence gating to construct a depth-resolved structural feature vector quantifying sub-resolution axial ...
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    In vivo correlation mapping microscopy 

    McGrath, James; Alexandrov, Sergey; Owens, Peter; Subhash, Hrebesh; Leahy, Martin (Society of Photo-optical Instrumentation Engineers (SPIE), 2016-03)
    To facilitate regular assessment of the microcirculation in vivo, noninvasive imaging techniques such as nailfold capillaroscopy are required in clinics. Recently, a correlation mapping technique has been applied to optical ...
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    Investigation of nanoscale structural alterations of cell nucleus as an early sign of cancer 

    Alexandrov, Sergey (BioMed Central, 2014)
    Background: The cell and tissue structural properties assessed with a conventional bright-field light microscope play a key role in cancer diagnosis, but they sometimes have limited accuracy in detecting early-stage cancers ...
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    Novel approach for label free super-resolution imaging in far field 

    Alexandrov, Sergey; McGrath, James; Hrebesh, Subhash; Leahy, Martin (Nature Publishing Group, 2015)
    Progress in the emerging areas of science and technology, such as bio- and nano-technologies, depends on development of corresponding techniques for imaging and probing the structures with high resolution. Recently, the ...
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    Nano-sensitive optical coherence tomography 

    Alexandrov, Sergey; Subhash, Hrebesh M.; Zam, Azhar; Leahy, Martin (Royal Society of Chemistry, 2014)
    Depth resolved label-free detection of structural changes with nanoscale sensitivity is an outstanding problem in the biological and physical sciences and has significant applications in both the fundamental research and ...
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    Performance review of multiple reference versus time domain optical coherence tomography 

    Neuhaus, Kai; McNamara, Paul M.; Alexandrov, Sergey; O'Gorman, Seán; Hogan, Josh; Wilson, Carol; Leahy, Martin J. (IEEE, 2018-04-19)
    We present a detailed characterization of noise sources in multiple reference optical coherence tomography (MR-OCT) compared to time-domain OCT (TD-OCT). The noise characteristics were modeled based on the TD-OCT noise ...
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    Nanosensitive optical coherence tomography for the study of changes in static and dynamic structures 

    Subhash, Hrebesh M.; Leahy, Martin; Alexandrov, Sergey (IOP Science, 2014-03-06)
    We briefly discuss the principle of image formation in Fourier domain optical coherence tomography (OCT). The theory of a new approach to improve dramatically the sensitivity of conventional OCT is described. The approach ...
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    Spatial frequency domain correlation mapping optical coherence tomography for nanoscale structural characterization 

    Alexandrov, Sergey; McNamara, Paul M.; Das, Nandan; Zhou, Yi; Lynch, Gillian; Hogan, Josh; Leahy, Martin (AIP Publishing, 2019-09-16)
    Most of the fundamental pathological processes in living tissues exhibit changes at the nanoscale. Noninvasive, label-free detection of structural changes in biological samples pose a significant challenge to both researchers ...
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    Label free ultra-sensitive imaging with sub-diffraction spatial resolution 

    Alexandrov, Sergey; Das, Nandan; McGrath, James; Owens, Peter; Sheppard, Colin J. R.; Boccafoschi, Francesca; Giannini, Cinzia; Sibillano, Teresa; Subhash, Hrebesh; Leahy, Martin (IEEE, 2019-07-09)
    In this paper, we show a new way to break the resolution limit and dramatically improve sensitivity to structural changes. To realize it we developed a novel label free contrast mechanism, based on the spectral encoding ...
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    Ultra-sensitive label free imaging below the resolution limit 

    Alexandrov, Sergey; McGrath, James; Sheppard, Colin J. R.; Boccafoschi, Francesca; Giannini, Cinzia; Sibillano, Teresa; Subhash, Hrebesh; Hogan, Josh; Leahy, James J. (SPIE (Society of Photo-optical Instrumentation Engineers) Digital Library, 2019-02-02)
    Almost all known nanoscopy methods rely upon the contrast created by fluorescent labels attached to the object of interest. This causes limitations on their applicability to in vivo imaging. A new label-free spectral ...
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