Browsing School of Physics by Author "Das, Nandan"
Now showing items 1-6 of 6
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1064 nm acoustic resolution photoacoustic microscopy
Periyasamy, Vijitha; Das, Nandan; Sharma, Arunima; Pramanik, Manojit (Wiley, 2018-12-03)Photoacoustic imaging is a noninvasive imaging technique having the advantages of high-optical contrast and good acoustic resolution at improved imaging depths. Light transport in biological tissues is mainly characterized ... -
Characterization of nanosensitive multifractality in submicron scale tissue morphology and its alteration in tumor progression
Das, Nandan; Alexandrov, Sergey; Gilligan, Katie E.; Dwyer, Róisín M.; Saager, Rolf B.; Ghosh, Nirmalya; Leahy, Martin (Society of Photo-optical Instrumentation Engineers, 2021-01-11)Significance: Assessment of disease using optical coherence tomography is an actively investigated problem, owing to many unresolved challenges in early disease detection, diagnosis, and treatment response monitoring. The ... -
Label free ultra-sensitive imaging with sub-diffraction spatial resolution
Alexandrov, Sergey; Das, Nandan; McGrath, James; Owens, Peter; Sheppard, Colin J. R.; Boccafoschi, Francesca; Giannini, Cinzia; Sibillano, Teresa; Subhash, Hrebesh; Leahy, Martin (IEEE, 2019-07-09)In this paper, we show a new way to break the resolution limit and dramatically improve sensitivity to structural changes. To realize it we developed a novel label free contrast mechanism, based on the spectral encoding ... -
Nanoscale structure detection and monitoring of tumour growth with optical coherence tomography
Das, Nandan; Sergey, Alexandrov; Zhou, Yi; Gilligan, Katie E.; Dwyer, Róisín M.; Leahy, Martin (Royal Society of Chemistry, 2020-05-25)Approximately 90% of cancers originate in epithelial tissues leading to epithelial thickening, but the ultrastructural changes and underlying architecture are less well known. Depth resolved label free visualization of ... -
Noninvasive detection of nanoscale structural changes in cornea associated with cross-linking treatment
Zhou, Yi; Alexandrov, Sergey; Nolan, Andrew; Das, Nandan; Dey, Rajib; Leahy, Martin (Wiley, 2020-02-17)Corneal cross-linking (CXL) using ultraviolet-A (UVA) irradiation with a riboflavin photosensitizer has grown from an interesting concept to a practical clinical treatment for corneal ectatic diseases globally, such as ... -
Spatial frequency domain correlation mapping optical coherence tomography for nanoscale structural characterization
Alexandrov, Sergey; McNamara, Paul M.; Das, Nandan; Zhou, Yi; Lynch, Gillian; Hogan, Josh; Leahy, Martin (AIP Publishing, 2019-09-16)Most of the fundamental pathological processes in living tissues exhibit changes at the nanoscale. Noninvasive, label-free detection of structural changes in biological samples pose a significant challenge to both researchers ...