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dc.contributor.authorFuchs, Anke
dc.contributor.authorGliwinski, Mateusz
dc.contributor.authorGrageda, Nathali
dc.contributor.authorSpiering, Rachel
dc.contributor.authorAbbas, Abul K.
dc.contributor.authorAppel, Silke
dc.contributor.authorBacchetta, Rosa
dc.contributor.authorBattaglia, Manuela
dc.contributor.authorBerglund, David
dc.contributor.authorBlazar, Bruce
dc.contributor.authorBluestone, Jeffrey A.
dc.contributor.authorBornhaeuser, Martin
dc.contributor.authorten Brinke, Anja
dc.contributor.authorBrusko, Todd M.
dc.contributor.authorCools, Nathalie
dc.contributor.authorCuturi, Maria Cristina
dc.contributor.authorGeissler, Edward
dc.contributor.authorGiannoukakis, Nick
dc.contributor.authorGolab, Karolina
dc.contributor.authorHafler, David A.
dc.contributor.authorvan Ham, S. Marieke
dc.contributor.authorHester, Joanna
dc.contributor.authorHippen, Keli
dc.contributor.authorDi Ianni, Mauro
dc.contributor.authorIlic, Natasa
dc.contributor.authorIsaacs, John
dc.contributor.authorIssa, Fadi
dc.contributor.authorIwaszkiewicz-Grzes, Dorota
dc.contributor.authorJaeckel, Elmar
dc.contributor.authorJoosten, Irma
dc.contributor.authorKlatzmann, David
dc.contributor.authorKoenen, Hans
dc.contributor.authorvan Kooten, Cees
dc.contributor.authorKorsgren, Olle
dc.contributor.authorKretschmer, Karsten
dc.contributor.authorLevings, Megan
dc.contributor.authorMarek-Trzonkowska, Natalia Maria
dc.contributor.authorMartinez-Llordella, Marc
dc.contributor.authorMiljkovic, Djordje
dc.contributor.authorMills, Kingston H. G.
dc.contributor.authorMiranda, Joana P.
dc.contributor.authorPiccirillo, Ciriaco A.
dc.contributor.authorPutnam, Amy L.
dc.contributor.authorRitter, Thomas
dc.contributor.authorRoncarolo, Maria Grazia
dc.contributor.authorSakaguchi, Shimon
dc.contributor.authorSanchez-Ramon, Silvia
dc.contributor.authorSawitzki, Birgit
dc.contributor.authorSofronic-Milosavljevic, Ljiljana
dc.contributor.authorSykes, Megan
dc.contributor.authorTang, Qizhi
dc.contributor.authorVives-Pi, Marta
dc.contributor.authorWaldmann, Herman
dc.contributor.authorWitkowski, Piotr
dc.contributor.authorWood, Kathryn J.
dc.contributor.authorGregori, Silvia
dc.contributor.authorHilkens, Catharien M. U.
dc.contributor.authorLombardi, Giovanna
dc.contributor.authorLord, Phillip
dc.contributor.authorMartinez-Caceres, Eva M.
dc.contributor.authorTrzonkowski, Piotr
dc.identifier.citationFuchs, A;Gliwinski, M;Grageda, N;Spiering, R;Abbas, AK;Appel, S;Bacchetta, R;Battaglia, M;Berglund, D;Blazar, B;Bluestone, JA;Bornhauser, M;ten Brinke, A;Brusko, TM;Cools, N;Cuturi, MC;Geissler, E;Giannoukakis, N;Golab, K;Hafler, DA;van Ham, SM;Hester, J;Hippen, K;Di Ianni, M;Ilic, N;Isaacs, J;Issa, F;Iwaszkiewicz-Grzes, D;Jaeckel, E;Joosten, I;Klatzmann, D;Koenen, H;van Kooten, C;Korsgren, O;Kretschmer, K;Levings, M;Marek-Trzonkowska, NM;Martinez-Llordella, M;Miljkovic, D;Mills, KHG;Miranda, JP;Piccirillo, CA;Putnam, AL;Ritter, T;Roncarolo, MG;Sakaguchi, S;Sanchez-Ramon, S;Sawitzki, B;Sofronic-Milosavljevic, L;Sykes, M;Tang, QZ;Vives-Pi, M;Waldmann, H;Witkowski, P;Wood, KJ;Gregori, S;Hilkens, CMU;Lombardi, G;Lord, P;Martinez-Caceres, EM;Trzonkowski, P (2018) 'Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization'. Frontiers In Immunology, 8(1844). doi: 10.3389/fimmu.2017.01844en_IE
dc.description.abstractCellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons of the results between the studies performed. While the number of clinical trials testing Tregs is already substantial, it seems to be crucial to provide some standardized characteristics of Treg products in order to minimize the problem. We have previously developed reporting guidelines called minimum information about tolerogenic antigen-presenting cells, which allows the comparison between different preparations of tolerance-inducing antigen-presenting cells. Having this experience, here we describe another minimum information about Tregs (MITREG). It is important to note that MITREG does not dictate how investigators should generate or characterize Tregs, but it does require investigators to report their Treg data in a consistent and transparent manner. We hope this will, therefore, be a useful tool facilitating standardized reporting on the manufacturing of Tregs, either for research purposes or for clinical application. This way MITREG might also be an important step toward more standardized and reproducible testing of the Tregs preparations in clinical applications.en_IE
dc.description.sponsorshipThis work was supported by a grant from the European Cooperation in Science and Technology (COST) for the AFACTT project (Action to Focus and Accelerate Cell-based Tolerance-inducing Therapies; BM1305). COST is part of the EU Framework Programme Horizon 2020.en_IE
dc.publisherFrontiers Mediaen_IE
dc.relation.ispartofFrontiers In Immunologyen
dc.titleMinimum information about T Regulatory Cells: A step toward reproducibility and standardizationen_IE
dc.contributor.funderEU Horizon 2020
dc.local.contactThomas Ritter, School Of Medicine, Regenerative Medicine Institute, Biosciences, Dangan. 5329 Email:

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