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dc.contributor.authorLomas, A.J.
dc.contributor.authorRyan, C.N.M.
dc.contributor.authorSorushanova, A.
dc.contributor.authorShologu, N.
dc.contributor.authorSideri, A.I.
dc.contributor.authorTsioli, V.
dc.contributor.authorFthenakis, G.C.
dc.contributor.authorTzora, A.
dc.contributor.authorSkoufos, I.
dc.contributor.authorQuinlan, Leo R.
dc.contributor.authorÓ Laighin, Gearóid
dc.contributor.authorMullen, A.M.
dc.contributor.authorKelly, A.M.
dc.contributor.authorKearns, J.L.
dc.contributor.authorBiggs, S.
dc.contributor.authorPandit, Abhay
dc.contributor.authorZeugolis, Dimitrios I.
dc.date.accessioned2018-01-26T12:43:41Z
dc.date.available2018-01-26T12:43:41Z
dc.date.issued2015-04
dc.identifier.citationLomas, A. J., Ryan, C. N. M., Sorushanova, A., Shologu, N., Sideri, A. I., Tsioli, V. Fthenakis, G. C., Tzora, A., Skoufos, I., Quinlan, L. R., O'Laighin, G., Mullen, A. M., Kelly, J. L., Kearns, S., Biggs, M., Pandit, A. , Zeugolis, D. I. (2015). The past, present and future in scaffold-based tendon treatments. Advanced Drug Delivery Reviews, 84, 257-277. doi: https://doi.org/10.1016/j.addr.2014.11.022en_IE
dc.identifier.issn1872-8294
dc.identifier.urihttp://hdl.handle.net/10379/7113
dc.description.abstractTendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics/biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come. (C) 2014 Elsevier B.V. All rights reserved.en_IE
dc.description.sponsorshipThis work is supported by the: EU FP7/2007–2013, Marie Curie, IAPP award, part of the People programme, Tendon Regeneration Project (Grant Agreement Number: 251385) to D.Z.; EU FP7/2007–2013, NMP award, Green Nano Mesh Project (Grant Agreement Number: 263289) to D.Z.; Science Foundation Ireland (Project Number: SFI_09-RFP-ENM2483) to D.Z.; Health Research Board, Health Research Awards Programme, under the grant agreement number HRA_POR/2011/84 to D.Z.; Enterprise Ireland, Collaborative Centre for Applied Nanotechnology (Project No: CCIRP-2007-CCAN-0509), under the Irish Government's National Development Plan 2007–2013 to D.Z.; Teagasc, Department of Agriculture, Food and Marine, FIRM/RSF/CoFORD (Project Number: 11-F-043) to D.Z.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofAdvanced Drug Delivery Reviewsen
dc.subjectHuman and equine tendon injuryen_IE
dc.subjectTendon cellular and extracellular compositionen_IE
dc.subjectTendon healingen_IE
dc.subjectTissue graftsen_IE
dc.subjectBiomaterialsen_IE
dc.subjectSustained and localised delivery of therapeutics/biologicsen_IE
dc.subjectANTERIOR CRUCIATE-LIGAMENTen_IE
dc.subjectPLATELET-RICH PLASMAen_IE
dc.subjectMESENCHYMAL STEM-CELLSen_IE
dc.subjectDIGITAL FLEXOR TENDONen_IE
dc.subjectTISSUE ENGINEERING APPLICATIONSen_IE
dc.subjectHUMAN ACHILLES-TENDONen_IE
dc.subjectMARROW STROMAL CELLSen_IE
dc.subjectROTATOR CUFF REPAIRen_IE
dc.subjectGROWTH-FACTOR SUPPLEMENTATIONen_IE
dc.subjectPROXIMAL SUSPENSORY DESMITISen_IE
dc.titleThe past, present and future in scaffold-based tendon treatmentsen_IE
dc.typeArticleen_IE
dc.date.updated2017-04-03T12:53:46Z
dc.identifier.doi10.1016/j.addr.2014.11.022
dc.local.publishedsourcehttps://doi.org/10.1016/j.addr.2014.11.022en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderScience Foundation Ireland
dc.contributor.funderEU Framework Programme 7
dc.internal.rssid9391493
dc.local.contactLeo Quinlan, Dept. Of Physiology, Quadrangle Building, Nui Galway. 3710 Email: leo.quinlan@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionACCEPTED
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